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?Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes?

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?Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes?

dc.contributor.author	Castillo Dalí, Gabriel	es
dc.contributor.author	Castillo de Oyagüe, Raquel	es
dc.contributor.author	Batista Cruzado, Antonio	es
dc.contributor.author	López Santos, Carmen	es
dc.contributor.author	Rodríguez González Elipe, Agustín	es
dc.contributor.author	Saffar, Jean Louis	es
dc.contributor.author	Lynch, Christopher D.	es
dc.contributor.author	Gutiérrez Pérez, José Luis	es
dc.contributor.author	Torres-Lagares, Daniel	es
dc.date.accessioned	2017-07-24T07:14:30Z
dc.date.available	2017-07-24T07:14:30Z
dc.date.issued	2017	es
dc.identifier.citation	Castillo Dalí, Gabriel ; Castillo de Oyagüe, Raquel ; Batista Cruzado, Antonio ; López Santos, Carmen ; Rodríguez González Elipe, Agustín ; Saffar, Jean Louis ; Lynch, Christopher D. ; Gutiérrez Pérez, José Luis ; Torres-Lagares, Daniel. ?Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes?. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 2 2017: 15-	es
dc.identifier.uri	http://hdl.handle.net/10550/59827
dc.description.abstract	The use of cold plasmas may improve the surface roughness of poly(lactic-co-glycolic) acid (PLGA) membranes, which may stimulate the adhesion of osteogenic mediators and cells, thus accelerating the biodegradation of the barriers. Moreover, the incorporation of metallic-oxide particles to the surface of these membranes may enhance their osteoinductive capacity. Therefore, the aim of this paper was to evaluate the reliability of a new PLGA membrane after being treated with oxygen plasma (PO2) plus silicon dioxide (SiO2) layers for guided bone regeneration (GBR) processes. Circumferential bone defects (diameter: 11 mm; depth: 3 mm) were created on the top of eight experimentation rabbits? skulls and were randomly covered with: (1) PLGA membranes (control), or (2) PLGA/PO2/SiO2 barriers. The animals were euthanized two months afterwards. A micromorphologic study was then performed using ROI (region of interest) colour analysis. Percentage of new bone formation, length of mineralised bone, concentration of osteoclasts, and intensity of ostheosynthetic activity were assessed and compared with those of the original bone tissue. The Kruskal-Wallis test was applied for between-group com Asignificance level of a=0.05 was considered. The PLGA/PO2/SiO2 membranes achieved the significantly highest new bone formation, length of mineralised bone, concentration of osteoclasts, and ostheosynthetic activity. The percentage of regenerated bone supplied by the new membranes was similar to that of the original bone tissue. Unlike what happened in the control group, PLGA/PO2/SiO2 membranes predominantly showed bone layers in advanced stages of formation. The addition of SiO2 layers to PLGA membranes pre-treated with PO2 improves their bone-regeneration potential. Although further research is necessary to corroborate these conclusions in humans, this could be a promising strategy to rebuild the bone architecture prior to rehabilitate edentulous areas.	es
dc.title	?Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes?	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.21512	es
dc.type.hasVersion	VoR	es_ES