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Periodontal and biochemical bone metabolism assessment on a chronic oral anticoagulation population treated with dicoumarins

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Periodontal and biochemical bone metabolism assessment on a chronic oral anticoagulation population treated with dicoumarins

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dc.contributor.author López Lacomba, Daniel es
dc.contributor.author Roa, Antonio es
dc.contributor.author González Jaranay, Maximino es
dc.contributor.author Gómez Moreno, Gerardo es
dc.contributor.author Moreu Burgos, Gerardo es
dc.date.accessioned 2017-07-24T07:14:30Z
dc.date.available 2017-07-24T07:14:30Z
dc.date.issued 2017 es
dc.identifier.citation López Lacomba, Daniel ; Roa, Antonio ; González Jaranay, Maximino ; Gómez Moreno, Gerardo ; Moreu Burgos, Gerardo. Periodontal and biochemical bone metabolism assessment on a chronic oral anticoagulation population treated with dicoumarins. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 2 2017: 17- es
dc.identifier.uri http://hdl.handle.net/10550/59828
dc.description.abstract The aim is to evaluate periodontal alteration and biochemical markers associated with bone turnover in chronic oral with dicoumarins anticoagulant treatment patients. 80 patients treated with oral anticoagulants were divided into 2 cohort: Group A (n=36) 6 month to 1 year with anticoagulant treatment and Group B (n=44) > 2 years with anticoagulant treatment. Clinical evaluation included: Clinical attachment level (CAL), plaque index (PI) and gingival index (GI). Analytically biochemical parameters of bone remodeling (calcium and phosphorus), formation (total acid phosphatase, alkaline phosphatase and osteocalcin) and resorption (tartrate-resistant acid phosphatase and beta-crosslaps) were evaluated. High values of PI (67-100%) especially in men and in Group B were observed. Men with anticoagulation treatment length showed an increased GI (49.167 vs 78.083) while Group B women showed a decreased GI in comparison with Group A (59.389 vs 42.120). Women presented a greater average CAL than men as well as Group B vs Group A but without statistical significance. All biochemical markers were decreased respect to values of general population. Osteocalcin in GroupB women showed a statistically significant outcome vs GroupA (p=0.004). Acid phosphatase (total and tartrate-resistant) has a slight increase in Group B women versus Group A, and Beta-crosslap showed lower values in Group A men than Group B and slightly lower in Group A women versus Group B, without statistical significance. Patients showed a slight to moderate degree of periodontal affectation, especially gingivitis related to bacterial plaque. Periodontal disorders tended to be more severe in Group B. While bone remodeling showed an overall decrease with greater affectation of bone neoformation phenomena, bone destruction tended to recover and normalize in time. es
dc.title Periodontal and biochemical bone metabolism assessment on a chronic oral anticoagulation population treated with dicoumarins es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21567 es
dc.type.hasVersion VoR es_ES

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