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A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid for bone metastases from solid tumors

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A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid for bone metastases from solid tumors

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dc.contributor.author Manfredi, Maddalena es
dc.contributor.author Mergoni, Giovanni es
dc.contributor.author Goldoni, Matteo es
dc.contributor.author Salvagni, Stefania es
dc.contributor.author Merigo, Elisabetta es
dc.contributor.author Meleti, Marco es
dc.contributor.author Vescovi, Paolo es
dc.date.accessioned 2017-07-24T09:29:06Z
dc.date.available 2017-07-24T09:29:06Z
dc.date.issued 2017 es
dc.identifier.citation Manfredi, Maddalena ; Mergoni, Giovanni ; Goldoni, Matteo ; Salvagni, Stefania ; Merigo, Elisabetta ; Meleti, Marco ; Vescovi, Paolo. A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid for bone metastases from solid tumors. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 3 2017: 1- es
dc.identifier.uri http://hdl.handle.net/10550/59857
dc.description.abstract Background: The aim of this study was to evaluate the incidence and the risk factors of osteonecrosis of the jaw (ONJ) in a group of patients treated with zoledronic acid (ZA) for bone metastases from solid tumors and enrolled in a preventive dental program. Material and Methods: This 5-year retrospective longitudinal study included all consecutive oncological patients who underwent at least one infusion with ZA between 2004 and 2011 for bone metastases due to solid neoplasms. Results: Of the 156 patients enrolled in the study, 17 developed ONJ (10.89%). At the multivariate analysis, severe periodontal disease (P=0.025), tooth extraction (P<0.0001) and starting the preventive dental program after the beginning of ZA therapy (P=0.02) were the only factors which showed a significant association with the occurrence of ONJ. Conclusions: This study demonstrated the importance of beginning dental prevention before zoledronic acid exposure in reducing ONJ occurrence, especially in the long term. The results of this research show that control of periodontal disease and an increase in the time between tooth extraction and the first ZA administration are recommended in order to reduce the risk of ONJ development es
dc.title A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid for bone metastases from solid tumors es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21728 es
dc.type.hasVersion VoR es_ES

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