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Oral bisphosphonate-related osteonecrosis of the jaws : clinical characteristics of a series of 20 cases in Spain

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Oral bisphosphonate-related osteonecrosis of the jaws : clinical characteristics of a series of 20 cases in Spain

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dc.contributor.author Diniz Freitas, Márcio es
dc.contributor.author López-Cedrún Cembranos, José Luis es
dc.contributor.author Fernández Sanromán, J. es
dc.contributor.author García García, Abel es
dc.contributor.author Fernández Feijoo, Javier es
dc.contributor.author Diz Dios, Pedro es
dc.date.accessioned 2017-07-24T11:03:28Z
dc.date.available 2017-07-24T11:03:28Z
dc.date.issued 2012 es
dc.identifier.citation Diniz Freitas, Márcio ; López-Cedrún Cembranos, José Luis ; Fernández Sanromán, J. ; García García, Abel ; Fernández Feijoo, Javier ; Diz Dios, Pedro. Oral bisphosphonate-related osteonecrosis of the jaws : clinical characteristics of a series of 20 cases in Spain. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 5 2012: 19- es
dc.identifier.uri http://hdl.handle.net/10550/59882
dc.description.abstract Objective: The objective of this study was to define the clinical characteristics of osteonecrosis of the jaws (ONJ) induced by oral bisphosphonates in a series of patients from a circumscribed area in northwest Spain. Study Design: A retrospective multicentre study was undertaken in 3 hospitals in an area with a radius less than 100 km in the Autonomous Community of Galicia (Spain). The medical records were reviewed and an oral examination was performed of patients diagnosed with oral bisphosphonate-related ONJ in the previous 3 years. Results: We detected 20 cases of ONJ (24 lesions) related to oral bisphosphonates (alendronate [16 patients] and ibandronate [4 patients]), which were mainly administered as treatment for osteoporosis (17 patients). The mean interval between initiation of treatment and confirmation of a diagnosis of ONJ was 66±43 months (range, 6-132 months); in 7 patients (35%) the interval was less than 36 months. The past history revealed hypertension in 13 cases (65%) and diabetes in 4 (20%); 7 patients (35%) were on corticosteroid treatment. Oral surgery had been previously performed in 13 patients (65%) and the remaining 7 patients (35%) had removable dental prostheses. The lesions most frequently affected the posterior mandible (62.5%). The majority of the lesions (75%) were classified as stage 2, although lesions were identified in all established clinical stages (including 2 stage 0 lesions). Conclusion: In conclusion, in the present series, ONJ induced by oral bisphosphonates typically develops in women around 70 years of age, taking alendronate, that underwent oral surgery. Most lesions are located in the posterior mandible and are classified as stage 2 at diagnosis. Some patients presented no known risk factors, suggesting that there may be risk factors still to be identified. There are well-defined patterns of clinical presentation that can facilitate early diagnosis of ONJ. es
dc.title Oral bisphosphonate-related osteonecrosis of the jaws : clinical characteristics of a series of 20 cases in Spain es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.18041 es
dc.type.hasVersion VoR es_ES

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