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Primary oral melanoma : a histopathological and immunohistochemical study of 22 cases of Latin America

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Primary oral melanoma : a histopathological and immunohistochemical study of 22 cases of Latin America

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dc.contributor.author Andrade, Bruno Augusto Benevenuto de es
dc.contributor.author Toral Rizo, Víctor Hugo es
dc.contributor.author León, Jorge Esquiche es
dc.contributor.author Contreras Vidaurre, Elisa es
dc.contributor.author Carlos, Román es
dc.contributor.author Delagado Azañero, Wilson es
dc.contributor.author Mosqueda Taylor, Adalberto es
dc.contributor.author Almeida, Oslei Paes de es
dc.date.accessioned 2017-07-25T10:17:37Z
dc.date.available 2017-07-25T10:17:37Z
dc.date.issued 2012 es
dc.identifier.citation Andrade, Bruno Augusto Benevenuto de ; Toral Rizo, Víctor Hugo ; León, Jorge Esquiche ; Contreras Vidaurre, Elisa ; Carlos, Román ; Delagado Azañero, Wilson ; Mosqueda Taylor, Adalberto ; Almeida, Oslei Paes de. Primary oral melanoma : a histopathological and immunohistochemical study of 22 cases of Latin America. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 3 2012: 17- es
dc.identifier.uri http://hdl.handle.net/10550/59950
dc.description.abstract Objective: The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM). Study Design: Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67. Results: The mean age was 58 years and 14 cases were female. The main affected sites were the hard palate, followed by the upper gingiva. Microscopically, 15 cases presented level III of invasion, 2 cases were amelanotic and 13 showed a mixed epithelioid and plasmacytoid or spindle cells composition. Some cases showed necrosis, perivascular and perineural invasion. S-100 and HMB-45 were positive in all cases, but 3 cases were negative for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 15.51% to 63% of positive cells. Conclusion: S-100 and HMB-45 are more frequently expressed than Melan-A in primary oral melanomas and these markers are helpful to confirm the diagnosis. es
dc.title Primary oral melanoma : a histopathological and immunohistochemical study of 22 cases of Latin America es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.17588 es
dc.type.hasVersion VoR es_ES

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