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Double-application of platelet-rich plasma on bone healing in rabbits

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Double-application of platelet-rich plasma on bone healing in rabbits

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dc.contributor.author Özdemir, Burcu es
dc.contributor.author Kurti?, Bülent es
dc.contributor.author Tüter, Gülay es
dc.contributor.author Sengüven, Burcu es
dc.contributor.author Tokman, Benay es
dc.contributor.author Pinar, Selin es
dc.contributor.author Demirel, Ilkim es
dc.contributor.author Özcan, Gönen es
dc.date.accessioned 2017-07-26T06:39:15Z
dc.date.available 2017-07-26T06:39:15Z
dc.date.issued 2012 es
dc.identifier.citation Özdemir, Burcu ; Kurti?, Bülent ; Tüter, Gülay ; Sengüven, Burcu ; Tokman, Benay ; Pinar, Selin ; Demirel, Ilkim ; Özcan, Gönen. Double-application of platelet-rich plasma on bone healing in rabbits. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 1 2012: 4- es
dc.identifier.uri http://hdl.handle.net/10550/60014
dc.description.abstract Objective: Platelet-rich plasma (PRP) is considered to enhance bone formation especially at early stages of wound healing, depending on the limited and short life-span of platelets and growth factors. The aim of this study was to evaluate efficacy of double-application of PRP (DA-PRP) on bone healing in a rabbit calvarial defect model. Study design: Twenty-eight rabbits, each had two surgically prepared calvarial bone defects (10mm diameter), were included in this study and randomly divided into six groups. Defects (n=56) were treated with single-application of PRP (SA-PRP)(n=10), SA-PRP and beta-tricalciumphosphate (SA-PRP+TCP)(n=10), DA-PRP (n=8), DA-PRP and beta-tricalciumphosphate (DA-PRP+TCP)(n=8), beta-tricalciumphosphate (TCP)(n=10) or left empty (Control)(n=10). Animals were sacrificed at 30 days postoperatively. Results: The new bone (NB%) and defect fill (DF%) percentages were calculated from histological slides by image-analyzer software and statistically analysed. All test groups showed higher NB% than control, but differences among all groups were insignificant. The TCP treated groups had significantly higher DF% than groups treated without TCP, however the DF% differences between control, SA-PRP and DA-PRP or TCP, SA-PRP+TCP or DA-PRP+TCP were insignificant. Conclusion: Although new bone formation was histomorphologically remarkable at double-application PRP groups, statistical analyses of the histomorphometric data revealed no significant difference. © Medicina Oral S. L. es
dc.title Double-application of platelet-rich plasma on bone healing in rabbits es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.17336 es
dc.type.hasVersion VoR es_ES

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