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TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma

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TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma

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dc.contributor.author de Freitas Silva, Brunno Santos es
dc.contributor.author Yamamoto, Fernanda-Paula es
dc.contributor.author Corrêa Pontes, Flávia Sirotheau es
dc.contributor.author Cury, Sérgio Elias-Vieira es
dc.contributor.author Fonseca, Felipe Paiva es
dc.contributor.author Rebelo-Pontes, Hélder-Antônio es
dc.contributor.author Júnior, Décio-dos-Santos-Pinto es
dc.date.accessioned 2017-07-26T06:39:15Z
dc.date.available 2017-07-26T06:39:15Z
dc.date.issued 2012 es
dc.identifier.citation de Freitas Silva, Brunno Santos ; Yamamoto, Fernanda-Paula ; Corrêa Pontes, Flávia Sirotheau ; Cury, Sérgio Elias-Vieira ; Fonseca, Felipe Paiva ; Rebelo-Pontes, Hélder-Antônio ; Júnior, Décio-dos-Santos-Pinto. TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 1 2012: 14- es
dc.identifier.uri http://hdl.handle.net/10550/60017
dc.description.abstract Objectives: The aim of this study was to evaluate the immunoexpression of TWIST and p-Akt proteins in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC), correlating their expressions with the histological features of the lesions. Study design: Immunohistochemical studies were carried out on 10 normal oral epithelium, 30 OL and 20 OSCC formalin-fixed, paraffin-embedded tissue samples. Immunoperoxidase reactions for TWIST and p-Akt proteins were applied on the specimens and the positivity of the reactions was calculated for 1000 epithelial cells. Results: Kruskal-Wallis and Dunn's post tests revealed a significant difference in TWIST and p-Akt immunoexpression among normal oral mucosa, OL and OSCC. In addition, a significant positive correlation was found between TWIST and p-Akt expressions according to the Pearson's correlation test. Conclusions: The results obtained in the current study suggest that TWIST and p-Akt may participate of the multi-step process of oral carcinogenesis since its early stages. © Medicina Oral S. L. es
dc.title TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.17344 es
dc.type.hasVersion VoR es_ES

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