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Expression of the gene encoding secretor type galactoside 2 ? fucosyltransferase (FUT2) and ABH antigens in patients with oral lesions

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Expression of the gene encoding secretor type galactoside 2 ? fucosyltransferase (FUT2) and ABH antigens in patients with oral lesions

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dc.contributor.author Campi, Carlos es
dc.contributor.author Escovich, Livia es
dc.contributor.author Moreno, Alejandra es
dc.contributor.author Racca, Liliana es
dc.contributor.author Racca, Amelia es
dc.contributor.author Cotorruelo, Carlos es
dc.contributor.author Biondi, Claudia es
dc.date.accessioned 2017-07-26T06:39:16Z
dc.date.available 2017-07-26T06:39:16Z
dc.date.issued 2012 es
dc.identifier.citation Campi, Carlos ; Escovich, Livia ; Moreno, Alejandra ; Racca, Liliana ; Racca, Amelia ; Cotorruelo, Carlos ; Biondi, Claudia. Expression of the gene encoding secretor type galactoside 2 ? fucosyltransferase (FUT2) and ABH antigens in patients with oral lesions. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 1 2012: 20- es
dc.identifier.uri http://hdl.handle.net/10550/60021
dc.description.abstract Objective: The aim of this work was to evaluate the expression of FUT2 gene in saliva and histo ABH antigens of patients with oral lesions. Study Design: In total 178 subjects were examined, half of whom suffered from oral pre-cancerous and cancerous lesions, while the other half were the healthy control group We analyzed the FUT 2 polymorphism by ASO-PCR (allele specific oligonucleotid - polymerase chain reaction) with specific primers for G428 allele and the wild type allele of FUT2 gene. To reveal A, B and H antigens in tissue sections of the patients (n= 89) we used a modified specific red cell adherence technique. Results: We found a high intensity of oral disease in the non-secretor group (OR = 2.43). A total of 58% of the patients with oral pre-cancerous and cancerous lesions was non secretors (se_/_), in contrast with the healthy population (21.5%). A strongly positive reaction was defined as a sheet of indicator erythrocytes adhered to the epithelial cells. In 31 of the 54 samples analyzed the test showed slightly positive results on atypical areas, and there was a complete antigen deletion in areas affected by neoplasia. Nineteen samples showed a total absence of ABH antigens in both histologically normal and pathological areas. Blood group antigens were expressed at a high level in benign and highly differentiated malignant tumors. In poorly differentiated malignant tumors, they were mostly absent. Conclusion: Considering these results we suggest the use of this method to monitor probable preneoplastic lesions in risk population, especially in those with no secretor status (absence of FUT2 gene). © Medicina Oral S. L. es
dc.title Expression of the gene encoding secretor type galactoside 2 ? fucosyltransferase (FUT2) and ABH antigens in patients with oral lesions es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.17239 es
dc.type.hasVersion VoR es_ES

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