NAGIOS: RODERIC FUNCIONANDO

Comparison of two histopathologic methods for evaluating subcutaneous reaction to mineral trioxide aggregate

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Comparison of two histopathologic methods for evaluating subcutaneous reaction to mineral trioxide aggregate

dc.contributor.author	Vosoughhosseini, Sepideh	es
dc.contributor.author	Lotfi, Mehrdad	es
dc.contributor.author	Moradzadeh, Monir	es
dc.contributor.author	Aghbali, Amirala	es
dc.contributor.author	Rahimi, Saeed	es
dc.contributor.author	Saghiri, Mohammadali	es
dc.contributor.author	Zand, Vahid	es
dc.contributor.author	Mehdipour, Masoumeh	es
dc.contributor.author	Ranjkesh, Bahram	es
dc.contributor.author	Doosti, Sirvan	es
dc.date.accessioned	2017-07-26T06:41:47Z
dc.date.available	2017-07-26T06:41:47Z
dc.date.issued	2012	es
dc.identifier.citation	Vosoughhosseini, Sepideh ; Lotfi, Mehrdad ; Moradzadeh, Monir ; Aghbali, Amirala ; Rahimi, Saeed ; Saghiri, Mohammadali ; Zand, Vahid ; Mehdipour, Masoumeh ; Ranjkesh, Bahram ; Doosti, Sirvan. Comparison of two histopathologic methods for evaluating subcutaneous reaction to mineral trioxide aggregate. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 1 2012: 16-	es
dc.identifier.uri	http://hdl.handle.net/10550/60031
dc.description.abstract	Objectives: One of the most important factors for suitable materials for pulp therapy is biocompatibility. Two histopathologic methods of Cox and Federation Dentaire International (FDI) were used to evaluate inflammation. In Cox method, density of inflammatory cells, tissue reactions like fibrosis, vascular responses like congestion and fibrin extravasation have been used to evaluate inflammatory reactions. The aim of this study was to compare the accuracy of pathologists' interpretations using two different methods. Study design: Three pathologists observed the degree of inflammation in 225 histopathologic sections. These se-ctions showed inflammation in subcutaneous connective tissue of rats adjacent to polyethylene tubes, filled with white or gray mineral trioxide aggregate. Empty tubes served as controls. Samples were harvested after 7-, 15-, 30-, 60-, and 90-days. All pathologists examined the sections under a light microscope (Carl Zeiss, Oberkochen, Germany) at ×400 magnifications. Chi-Square test was used to evaluate the difference between inflammation grades when one pathologist used two methods. Cohen's Kappa value was used to measure agreement of three pathologists to recognize the degrees of inflammations when using one of the methods. Results: There were no significant differences between the two methods when one of the pathologist used these me-thods to report the degree of inflammation (p=0.054). However, two other pathologists reported significant differences between two methods (p=0.005, p=0.001). In the FDI method, there was an acceptable agreement between first and second, and first and third pathologist in terms of the degree of inflammation, and intermediate agreement existed between the second and third pathologist. With the Cox method, no agreement among the pathologists could be found. Conclusion: The results of three pathologists in terms of rating inflammation with the FDI method showed better agreement than with the Cox method. Therefore, FDI method is more reliable than the Cox method to evaluate inflammation. © Medicina Oral S. L.	es
dc.title	Comparison of two histopathologic methods for evaluating subcutaneous reaction to mineral trioxide aggregate	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.17309	es
dc.type.hasVersion	VoR	es_ES