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Microbiological effects of an antiseptic mouthrinse in irradiated cancer patients

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Microbiological effects of an antiseptic mouthrinse in irradiated cancer patients

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dc.contributor.author Lanzós, Isabel es
dc.contributor.author Herrera, David es
dc.contributor.author Santos, Sagrario es
dc.contributor.author O'Connor, Ana es
dc.contributor.author Peña, Carmen es
dc.contributor.author Lanzos González, Eduardo es
dc.contributor.author Sanz Alonso, Mariano es
dc.date.accessioned 2017-07-26T08:27:12Z
dc.date.available 2017-07-26T08:27:12Z
dc.date.issued 2011 es
dc.identifier.citation Lanzós, Isabel ; Herrera, David ; Santos, Sagrario ; O'Connor, Ana ; Peña, Carmen ; Lanzos González, Eduardo ; Sanz Alonso, Mariano. Microbiological effects of an antiseptic mouthrinse in irradiated cancer patients. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 16 7 2011: 30- es
dc.identifier.uri http://hdl.handle.net/10550/60063
dc.description.abstract Objective: To assess the microbiological effects of an antiseptic, non-alcohol based mouth-rinse containing chlorhexidine and cetylpyridinium chloride, in patients undergoing radiation therapy for head-and-neck cancer. Study Design: This was a parallel, double-blind, prospective, randomized clinical trial, including patients irradiated as part of the therapy of head-and-neck cancer, aged 18-75, with at least 10 teeth, and willing to sign an informed consent. Cancer patients were randomly assigned to one of the two treatments (test mouth-rinse or a placebo). Three visits were scheduled (baseline, 14 and 28 days). Microbiological findings were evaluated in tongue, mucosa and subgingival samples, by means of culture. Microbiological variables were assessed by means of the Mann-Whitney, Wilcoxon and chi-square tests. Results: 70 patients were screened and 36 were included. The detection of Candida species in mucosa and tongue samples showed significant reductions in the test group. Total bacterial counts decreased in both groups from baseline to the 2-week visit, while minor changes occurred between 2 and 4 weeks (effects on P. gingivalis, P. intermedia, C. rectus, E. corrodens). Conclusions: Within the limitations of the small sample size, this study suggests that the use of the tested mouth-rinse may lead to improvements in microbiological parameters in patients irradiated for head-and-neck cancer. © Medicina Oral S. L. es
dc.title Microbiological effects of an antiseptic mouthrinse in irradiated cancer patients es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.17234 es
dc.type.hasVersion VoR es_ES

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