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Analysis of a possible association between oral lichen planus and drug intake. A controlled study

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Analysis of a possible association between oral lichen planus and drug intake. A controlled study

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dc.contributor.author Hirota, Silvio K. es
dc.contributor.author Moreno, Ricardo A. es
dc.contributor.author dos Santos, Carlos H. R. es
dc.contributor.author Seo, Juliana es
dc.contributor.author Migliari, Dante A. es
dc.date.accessioned 2017-07-26T10:35:18Z
dc.date.available 2017-07-26T10:35:18Z
dc.date.issued 2011 es
dc.identifier.citation Hirota, Silvio K. ; Moreno, Ricardo A. ; dos Santos, Carlos H. R. ; Seo, Juliana ; Migliari, Dante A.. Analysis of a possible association between oral lichen planus and drug intake. A controlled study. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 16 6 2011: 11- es
dc.identifier.uri http://hdl.handle.net/10550/60088
dc.description.abstract Objectives: To investigate whether daily systemic and/or topical medication contributes to the development of oral lichen planus (OLP) lesions. Study Design: The study involved 110 OLP patients and 76 control subjects, matched by age, race and sex. The analyzed data included medical records, drug intake and topical medication. Criteria for analysis of drug intake included: (1) ATC-code drug classification; (2) number of different drugs used daily in the categories of monopharmacy (1 drug), minor polypharmacy (2 4 drugs), and major polypharmacy (> 5 drugs); and (3) drugs implicated in lichenoid reactions (DILRs). Results: Sixty (54.5%) of the 110 OLP patients reported daily medication (prior to the appearance of the OLP lesion) compared to 52 (68.4%) of the 76 control subjects. No statistical difference was found between the two groups in terms of systemic diseases, number of medicated individuals in the categories of mono- and polypharmacy, nor use of DILRs (P > 0.05). Regarding the clinical forms and site of involvement, a statistically significant difference was only found for the clinical erosive form of OLP, seen more frequently in non-DILR (P = 0.04) and nonmedicated OLP patients (P = 0.02) than in DILR OLP patients. Daily use of topical oral medication was reported by 2 (1.8%) OLP patients and 1 (1.3%) control subject. Conclusions: It seems that the use of systemic medication does not lead to a significant increase in the incidence of OLP lesions. For their part, lichenoid drug reactions are likely to occur only in a very low percentage of patients. © Medicina Oral S. L. es
dc.title Analysis of a possible association between oral lichen planus and drug intake. A controlled study es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.17095 es
dc.type.hasVersion VoR es_ES

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