Objectives: The aim of the present study was to evaluate bone repair in defects induced in the cranium of Wistar rats using ?-tricalcium phosphate. Study Design: In this research, we used 30 rats, randomly distributed in three groups of 10 animals (G1, G2 and G3), corresponding respectively to time of histological evaluation (7, 15 and 30 days). This was a paired study, a defect being induced in the parietal bone on either side of the median sagittal suture of the animals, being the left-hand side the experimental subgroup (filled by biomaterial) and the right control. The histological evaluation was performed by means of light microscopy. The collected data were submitted to the Fisher Exact test for comparison between the groups and to the McNemar test for comparison between the subgroups (P > 5%). Results: The results showed no statistically significant differences between the groups and bone regeneration was similar at the different times of evaluation. Conclusions: Therefore, we concluded that ?-tricalcium phosphate has not contributed significantly to repair process of defects induced in the cranium of Wistar rats