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The neural histogenetic origin of the oral granular cell tumor : an immunohistochemical evidence

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The neural histogenetic origin of the oral granular cell tumor : an immunohistochemical evidence

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dc.contributor.author Rejas, Roberto A. García es
dc.contributor.author Campos, Marcia Sampaio es
dc.contributor.author Cortes, Arthur Rodriguez Gonzalez es
dc.contributor.author Júnior, Décio-dos-Santos-Pinto es
dc.contributor.author Sousa, Suzana COM de es
dc.date.accessioned 2017-07-27T06:47:38Z
dc.date.available 2017-07-27T06:47:38Z
dc.date.issued 2011 es
dc.identifier.citation Rejas, Roberto A. García ; Campos, Marcia Sampaio ; Cortes, Arthur Rodriguez Gonzalez ; Júnior, Décio-dos-Santos-Pinto ; Sousa, Suzana COM de. The neural histogenetic origin of the oral granular cell tumor : an immunohistochemical evidence. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 16 1 2011: 2- es
dc.identifier.uri http://hdl.handle.net/10550/60188
dc.description.abstract Aims: Granular cell tumor (GCT) is a rare neoplasm that can appear in any site of the body, but most are located intraorally. Its histogenetic origin remains unclear. This report analyzes the immunoprofile of 15 cases of granular cell tumors, occurring in 13 women and 2 men and the lesions were located on the tongue or upper lip. Patient age ranged from 7 to 52. Methods: The patients demographic data and the cytological and architectural features of the lesions were analyzed in oral GCTs (n = 15). The lesions were also submitted to a panel of immunohistochemical stains with antibodies against S-100, p75, NSE, CD-68, Ki-67, Synaptofisin, HHF-35, SMA, EMA, Chromogranin, Progesterone, Androgen and Estrogen. Results: Among the fifteen cases analyzed, the most common location was the tongue (84.6%). Histologically, the tumors exhibited cellular proliferation composed mainly by polygonal cells presenting an abundant granular eosinophilic cytoplasm. The nuclei were central, and the cell membranes were moderately clear. No mitotic figures were observed. The immunohistochemical analysis showed positivity in all cases for S-100, p75, NSE and CD-68, and no immunoreactivity for Ki-67, Synaptofisin, HHF-35, SMA, EMA, Chromogranin, Progesterone, Androgen and Estrogen. Conclusion: The immunoprofile of granular cell tumors showed nerve sheath differentiation ? lending support to their neural origin ? and helping to establish a differential diagnosis between this lesion and other oral granular cell tumors, whether benign or malignant. es
dc.title The neural histogenetic origin of the oral granular cell tumor : an immunohistochemical evidence es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.16.e6 es
dc.type.hasVersion VoR es_ES

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