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The influence of local anesthetic solutions storage on tissue inflammatory reaction

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The influence of local anesthetic solutions storage on tissue inflammatory reaction

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dc.contributor.author Berto, Luciana Aranha es
dc.contributor.author Groppo, Francisco Carlos es
dc.contributor.author Ramacciato, Juliana Cama es
dc.contributor.author Tofoli, Giovana es
dc.contributor.author Volpato, Maria Cristina es
dc.contributor.author Ranali, José es
dc.contributor.author Novaes, Pedro Duarte es
dc.contributor.author Motta, Rogério Heládio Lopes es
dc.date.accessioned 2017-07-27T06:48:48Z
dc.date.available 2017-07-27T06:48:48Z
dc.date.issued 2011 es
dc.identifier.citation Berto, Luciana Aranha ; Groppo, Francisco Carlos ; Ramacciato, Juliana Cama ; Tofoli, Giovana ; Volpato, Maria Cristina ; Ranali, José ; Novaes, Pedro Duarte ; Motta, Rogério Heládio Lopes. The influence of local anesthetic solutions storage on tissue inflammatory reaction. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 16 1 2011: 18- es
dc.identifier.uri http://hdl.handle.net/10550/60204
dc.description.abstract Objective: This study aimed to analyze the influence of storage conditions of local anesthetic solutions in the inflammatory reaction after injection in rats. Study design: Twenty-four rats received in their oral mucosa the injection of 2% lidocaine with epinephrine 1:100.000 solutions (LA) submitted to the following storage conditions during a twelve-month period: G1 - inside the original packaging, in refrigerator (5±1°C); G2 - inside the original box, under light shelter, at room temperature; G3 - outside the original box at room temperature (exposed to artificial light for 12 hours/day) and G4 - brand new solution. For the controls tests, 0.9% sodium chloride solution was injected in the opposite side. After 6 and 24 hours, three animals of each group were sacrificed and their maxilla along with the soft tissue were removed and submitted to histological analysis (HE). Results: The pH of LA was measured before and after the storage period and no statistically differences were observed between G1 and G4, but both were different from G2 and G3. All the scores of the testing solutions were higher than their respective negative controls, except for G1 at 6 hours. The order of the scores of inflammation after 6 hours was G3>G4>G2=G1. After 24 hours the order was G3>G2>G1>G4. Conclusion: The study showed that the method of storage can influence the pH and the level of inflammatory reaction after the injection of 2% lidocaine with epinephrine 1:100.000. es
dc.title The influence of local anesthetic solutions storage on tissue inflammatory reaction es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.16.e83 es
dc.type.hasVersion VoR es_ES

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