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Evaluation of the diagnostic value of a Modified Liquid-Based Cytology using OralCDx Brush in early detection of oral potentially malignant lesions and oral cancer

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Evaluation of the diagnostic value of a Modified Liquid-Based Cytology using OralCDx Brush in early detection of oral potentially malignant lesions and oral cancer

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dc.contributor.author Delavarian, Zarha es
dc.contributor.author Mohtasham, Nooshin es
dc.contributor.author Mosannen-Mozaffari, Pegah es
dc.contributor.author Pakfetrat, Atessa es
dc.contributor.author Shakeri, Mohammad-Taghi es
dc.contributor.author Ghafoorian Maddah, Rasoul es
dc.date.accessioned 2017-07-27T06:52:17Z
dc.date.available 2017-07-27T06:52:17Z
dc.date.issued 2010 es
dc.identifier.citation Delavarian, Zarha ; Mohtasham, Nooshin ; Mosannen-Mozaffari, Pegah ; Pakfetrat, Atessa ; Shakeri, Mohammad-Taghi ; Ghafoorian Maddah, Rasoul. Evaluation of the diagnostic value of a Modified Liquid-Based Cytology using OralCDx Brush in early detection of oral potentially malignant lesions and oral cancer. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 15 5 2010: 1- es
dc.identifier.uri http://hdl.handle.net/10550/60243
dc.description.abstract Objectives: To determine diagnostic value of modified Liquid Based Brush Biopsy technique. Study design: 26 oral premalignant and malignant lesions in 25 patients (12 females; 54.23±19.77 years and 13 males; 53.77±15.43 years) underwent Modified (Liquid Based) Brush Biopsy and scalpel biopsy simultaneously from the same area. Results: There were 16 positive and 10 negative brush biopsy results, with no inadequate readings. Histological findings were compatible with oral leukoplakia(n=5)with dysplasia, Oral lichen planus and lichenoid reaction(n=7) (with or without dysplasia)oral squamous cell carcinoma(n=11),verrucous carcinoma(n=1) and granular cell tumors( n=2). Sensitivity, specificity, positive predictive value, negative predictive value, positive diagnostic likelihood ratio(LR+) and negative diagnostic likelihood ratio(LR-) were 88.8%,100%,100% , 80%, infinity and 0.11 respectively(no false positive results). Conclusion: It is the first attempt to do LBC (liquid based cytology) with a specialized oral brush. Our results show that modified technique is a useful tool for screening of oral premalignant and malignant lesions. es
dc.title Evaluation of the diagnostic value of a Modified Liquid-Based Cytology using OralCDx Brush in early detection of oral potentially malignant lesions and oral cancer es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.15.e671 es
dc.type.hasVersion VoR es_ES

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