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Fibronectin as an adjuvant in the diagnosis of oral inflammatory myofibroblastic tumor

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Fibronectin as an adjuvant in the diagnosis of oral inflammatory myofibroblastic tumor

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dc.contributor.author Xavier, Flávia-Caló-de Aquino es
dc.contributor.author Rocha, André Caroli es
dc.contributor.author Sugaya, Norberto N. es
dc.contributor.author dos Santos Pinto Jr, Décio es
dc.contributor.author Sousa, Suzana COM de es
dc.date.accessioned 2017-09-07T10:21:43Z
dc.date.available 2017-09-07T10:21:43Z
dc.date.issued 2009 es
dc.identifier.citation Xavier, Flávia-Caló-de Aquino ; Rocha, André Caroli ; Sugaya, Norberto N. ; dos Santos Pinto Jr, Décio ; Sousa, Suzana COM de. Fibronectin as an adjuvant in the diagnosis of oral inflammatory myofibroblastic tumor. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 14 12 2009: 4- es
dc.identifier.uri http://hdl.handle.net/10550/60625
dc.description.abstract Inflammatory myofibroblastic tumor is a distinctive lesion composed of myofibroblastic spindle shaped cells accompanied by inflammatory infiltrate that may arise in various organs. It is believed to be a noneoplastic inflammatory condition, although this is still controversial. The recognition of inflammatory myofibroblastic tumor as an entity is important especially to avoid unnecessary surgery. A few cases have been reported in the oral cavity. This report primarily presents a case of inflammatory myofibroblastic tumor that arose in the floor of mouth of a 23-year-old woman. The proliferating spindle cells were immunoreactive for vimentin, smooth muscle actin, and muscle specific actin and negative for desmin, AE1/AE3, S-100, CD68, MyoD1 and caldesmon. In an attempt to assess the potential neoplastic nature of this lesion, immunohistochemical expression of ALK protein was performed, although no immunoreactivity was detected. Also, the presence of well differentiated myofibroblasts identified by fibronectin is discussed, as well as the importance in establishing an immunoprofile to better consolidate the diagnosis. We conclude that the study of fibronectin in case series may aid the diagnosis as well as the prediction of the tumor course. es
dc.title Fibronectin as an adjuvant in the diagnosis of oral inflammatory myofibroblastic tumor es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.14.e635 es
dc.type.hasVersion VoR es_ES

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