Diagnosis and prognosis of cardiovascular diseases by means of texture analysis in magnetic resonance imaging
Mostra el registre complet de l'element
Visualització
(6.890Mb)
|
|
|
|
|
|
Larroza Santacruz, Andrés Martín
Bodí Peris, Vicente (dir.);
Moratal Pérez, David (dir.)
Departament d'Enginyeria Electrònica
|
|
Aquest document és un/a tesi, creat/da en: 2017
|
|
Cardiovascular diseases constitute the leading global cause of morbidity and
mortality. Magnetic resonance imaging (MRI) has become the gold standard technique
for the assessment of patients with myocardial infarction. However, limitations still
exist thus new alternatives are open to investigation. Texture analysis is a technique
that aims to quantify the texture of the images that are not always perceptible by the
human eye. It has been successfully applied in medical imaging but applications to
cardiac MRI (CMR) are still scarce. Therefore, the purpose of this thesis was to apply
texture analysis in conventional CMR images for the assessment of patients with
myocardial infarction, as an alternative to current methods.
Three applications of texture analysis and machine learning techniques were studied:
i) Detection of infarcted myocardium in late gadolinium enhancement (LGE) CMR.
Segmentation of the infarcted myocardium is routinely performed using image
intensity thresholds. The inclusion of texture features to aid the segmentation
was analyzed obtaining overall good results. The method was developed using
10 LGE CMR datasets and tested on a separate dataset comprising 5 cases that
were acquired with a completely different scanner than that used for training.
Therefore, this preliminary study showed the transferability of texture analysis
which is important for clinical applicability.
ii) Differentiation of acute and chronic myocardial infarction using LGE CMR and
standard pre-contrast cine CMR. In this study, two different feature selection
techniques and six different machine learning classifiers were studied and
compared. The best classification was achieved using a polynomial SVM
obtaining an overall AUC of 0.87 ± 0.06 in LGE CMR. Interestingly, results on
cine CMR in which infarctions are visually imperceptible in most cases were also
good (AUC = 0.83 ± 0.08).
iii) Detection of infarcted non-viable segments in cine CMR. This study was
motivated by the findings of the previous one. It demonstrated that texture
analysis can be used to distinguish non-viable, viable and remote segments using
standard pre-contrast cine CMR solely. This was the most relevant contribution
of this thesis as it can be used as hypothesis for future work aiming to accurately
delineate the infarcted myocardium as a gadolinium-free alternative that will have potential advantages.
The three proposed applications were successfully performed obtaining promising
results. In conclusion, texture analysis can be successfully applied to conventional
CMR images and provides a potential quantitative alternative to existing methods.
|
|
Veure al catàleg Trobes
|
Aquest element apareix en la col·lecció o col·leccions següent(s)
Mostra el registre complet de l'element