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Gene therapy in the management of oral cancer: Review of the literature

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Gene therapy in the management of oral cancer: Review of the literature

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dc.contributor.author Ayllón Barbellido, Sonia es
dc.contributor.author Campo Trapero, Julián es
dc.contributor.author Cano Sánchez, Jorge es
dc.contributor.author Perea García, M.A. es
dc.contributor.author Escudero-Castaño, Nayra es
dc.contributor.author Bascones Martínez, Antonio es
dc.date.accessioned 2017-09-11T07:43:24Z
dc.date.available 2017-09-11T07:43:24Z
dc.date.issued 2008 es
dc.identifier.citation Ayllón Barbellido, Sonia ; Campo Trapero, Julián ; Cano Sánchez, Jorge ; Perea García, M.A. ; Escudero-Castaño, Nayra ; Bascones Martínez, Antonio. Gene therapy in the management of oral cancer: Review of the literature. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 13 1 2008: 4- es
dc.identifier.uri http://hdl.handle.net/10550/60655
dc.description.abstract Gene therapy essentially consists of introducing specific genetic material into target cells without producing toxic effects on surrounding tissue. Advances over recent decades in the surgical, radiotherapeutic and chemotherapeutic treatment of oral cancer patients have not produced a significant improvement in patient survival. Increasing interest is being shown in developing novel therapies to reverse oral epithelial dysplastic lesions. This review provides an update on transfer techniques, therapeutic strategies, and the clinical applications and limitations of gene therapy in the management of oral cancer and precancer. We highlight the combination of gene therapy with chemotherapy (e.g., 5-Fluoracil) and immunotherapy, given the promising results obtained in the use of adenovirus to act at altered gene level (e.g., p53). Other techniques such as suicide gene therapy, use of oncolytic viruses or the use of antisense RNA have shown positive although very preliminary results. Therefore, further research into these promising gene therapy techniques is required to assess their true efficacy and safety in the management of these lesions. es
dc.title Gene therapy in the management of oral cancer: Review of the literature es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es
dc.type.hasVersion VoR es_ES

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