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Bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma

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Bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma

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dc.contributor.author Infante Cossío, Pedro es
dc.contributor.author Cabezas Macián, Antonio es
dc.contributor.author Pérez Ceballos, José Luis es
dc.contributor.author Palomino Nicas, Julián es
dc.contributor.author Gutiérrez Pérez, José Luis es
dc.date.accessioned 2017-09-11T07:43:47Z
dc.date.available 2017-09-11T07:43:47Z
dc.date.issued 2008 es
dc.identifier.citation Infante Cossío, Pedro ; Cabezas Macián, Antonio ; Pérez Ceballos, José Luis ; Palomino Nicas, Julián ; Gutiérrez Pérez, José Luis. Bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 13 1 2008: 12- es
dc.identifier.uri http://hdl.handle.net/10550/60663
dc.description.abstract Purpose: To review the main clinical-radiographic, therapeutic, and preventive aspects of osteonecrosis related to intravenous bisphosphonate therapy in patients with multiple myeloma. Materials and methods: Between 2005 and 2006, we studied four patients with previous diagnosis of multiple myeloma treated with intravenous zoledronic acid, presenting nonhealing extraction sockets and intraoral exposed bone. We assessed the location of lesions, the relation with previous history of dento-alveolar surgery procedures, the clinical features, the treatments carried out, and the outcomes achieved. Results: All the patients were treated with chlorhexidine mouthwashes and oral amoxycilin-clavulanic acid for long periods of time. Two patients did not respond to the conservative management and needed surgical bone debridement. Conclusions: Dental extractions seem to contribute the development of osteonecrosis of the jaw in patients with multiple myeloma treated with intravenous bisphosphonate therapy. Whereas the pathologic mechanisms are not known, these patients should undergo frequent check-ups before, during, and after bisphosphonate therapy. The management must be symptomatic and palliative, including systemic antibiotics, control of pain, and chlorhexidine mouthwashes during long periods of time. es
dc.title Bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es
dc.type.hasVersion VoR es_ES

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