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Oncocytic metaplasia in inflammatory fibrous hyperplasia : histopathological and immunohistochemical analysis

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Oncocytic metaplasia in inflammatory fibrous hyperplasia : histopathological and immunohistochemical analysis

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dc.contributor.author Ayroza Rangel, Ana Lúcia Carrinho es
dc.contributor.author León, Jorge Esquiche es
dc.contributor.author Jorge, Jacks es
dc.contributor.author Lopes, Márcio Ajudarte es
dc.contributor.author Vargas, Pablo Agustín es
dc.date.accessioned 2017-09-13T06:58:24Z
dc.date.available 2017-09-13T06:58:24Z
dc.date.issued 2008 es
dc.identifier.citation Ayroza Rangel, Ana Lúcia Carrinho ; León, Jorge Esquiche ; Jorge, Jacks ; Lopes, Márcio Ajudarte ; Vargas, Pablo Agustín. Oncocytic metaplasia in inflammatory fibrous hyperplasia : histopathological and immunohistochemical analysis. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 13 3 2008: 1- es
dc.identifier.uri http://hdl.handle.net/10550/60757
dc.description.abstract Oncocytic metaplasia (OM) is not a well-known feature in inflammatory fibrous hyperplasia (IFH) lesions, although it may be common, as proposed in our previous study about this lesion. In the present paper, we assessed the histopathological and immunohistochemical features of 18 cases of IFH containing OM areas. All the samples were examined on haematoxylin and eosin stained sections and cytokeratins (AE1/AE3, 34ßE12, CK5, CK7, CK8, CK13, CK14 and CK19), CD15, CD20, CD68, CD45Ro, and LCA primary antibodies were used. The vast majority of IFH occurred in women (n=14) and the most common site of presentation was the buccal vestibule. Oncocytic and salivary duct cells showed uniform immunoreactivity for AE1/AE3, CK7, CK8 and CK19. CD45Ro+ T-lymphocytes were the most common inflammatory cells surrounding the OM areas followed by CD20+ B-lymphocytes. These findings suggest that oncocytic cells present in IFH might develop from salivary duct epithelium, and T-lymphocytes might play an important role in its etiopathogenesis. es
dc.title Oncocytic metaplasia in inflammatory fibrous hyperplasia : histopathological and immunohistochemical analysis es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es
dc.type.hasVersion VoR es_ES

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