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Metallothionein immunoexpression in oral leukoplakia

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Metallothionein immunoexpression in oral leukoplakia

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dc.contributor.author Johann, Aline Cristina Batista Rodrigues es
dc.contributor.author Silveira Júnior, João Batista es
dc.contributor.author Souto, Giovanna Ribeiro es
dc.contributor.author Horta, Martinho Campolina Rebello es
dc.contributor.author Aguiar, Maria Cássia Ferreira es
dc.contributor.author Mesquita, Ricardo Alves es
dc.date.accessioned 2017-09-13T06:59:12Z
dc.date.available 2017-09-13T06:59:12Z
dc.date.issued 2008 es
dc.identifier.citation Johann, Aline Cristina Batista Rodrigues ; Silveira Júnior, João Batista ; Souto, Giovanna Ribeiro ; Horta, Martinho Campolina Rebello ; Aguiar, Maria Cássia Ferreira ; Mesquita, Ricardo Alves. Metallothionein immunoexpression in oral leukoplakia. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 13 3 2008: 2- es
dc.identifier.uri http://hdl.handle.net/10550/60759
dc.description.abstract Objectives: to report the immunoexpression of metallothionein in oral leukoplakia and to correlate with histological grade and clinical localization. Leukoplakia is the most common potentially malignant lesion of the oral cavity. As the histological study of oral leukoplakia can not predict precisely the malignant transformation of this lesion, and metallothionein is a protein that has been associated with carcinogenesis, this study could be auxiliary in this histological assessment of this lesion. Study design: samples of oral leukoplakia (35 cases) and of normal oral mucosa (10 cases) were evaluated. Oral leukoplakia was graded in: hyperkeratosis without dysplasic change (9 cases), mild dysplasia (8 cases), moderated dysplasia (10 cases), and severe dysplasia (8 cases). Immunohistochemistry for the metallothionein was performed and the Mann-Whitney test was used in statistical analysis. Results: metallothionein was identified in squamous cells of the all samples. The metallothionein stain in all cases exhibit a mosaic pattern and was predominantly in compartments cytoplasmatic and nuclear simultaneously. The total stain was significantly higher in moderate dysplasia when compared with normal oral mucosa, hyperkeratosis, and mild dysplasia. Conclusion: it was suggested that the metallothionein may be a marker to moderate dysplasia and may play a role in oral carcinogenesis. es
dc.title Metallothionein immunoexpression in oral leukoplakia es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es
dc.type.hasVersion VoR es_ES

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