To evaluate the influence of thermal and mechanical fatigue on the shear bond strength of different all-ceramic cores and veneering porcelain interfaces. All-ceramic systems tested were lithium disilicate and zirconia veneered by layering technique. Sixty specimens (n=20) were subjected to shear bond strength. Ten of them were thermal and mechanical cycled. Fracture analysis was performed with stereomicroscopy and scanning electron microscopy. Energy dispersive X-ray spectroscopy analysis was performed across core/veneer interfaces. Thermal and mechanical cycling did not influence on bond strength. However, there was significant difference among systems (<0.01). CoCr group presented the highest values, followed by lithium disilicate, and zirconia. Failure modes were predominantly adhesive for CoCr, cohesive in core for lithium disilicate, and cohesive in veneer for zirconia. Energy dispersive X-ray showed interaction zone for CoCr and lithium disilicate groups and was inconclusive for zirconia. Fatigue had no influence on bond strength of groups tested. The results suggest that there is a chemical bond between core and veneer materials for CoCr and lithium disilicate groups.