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Secretor status and ABH antigens expression in patients with oral lesions

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Secretor status and ABH antigens expression in patients with oral lesions

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dc.contributor.author Campi, Carlos es
dc.contributor.author Escovich, Livia es
dc.contributor.author Valdés, Vanina es
dc.contributor.author García Borrás, Silvia es
dc.contributor.author Racca, Liliana es
dc.contributor.author Racca, Amelia es
dc.contributor.author Cotorruelo, Carlos es
dc.contributor.author Biondi, Claudia es
dc.date.accessioned 2017-11-20T12:32:07Z
dc.date.available 2017-11-20T12:32:07Z
dc.date.issued 2007 es
dc.identifier.citation Campi, Carlos ; Escovich, Livia ; Valdés, Vanina ; García Borrás, Silvia ; Racca, Liliana ; Racca, Amelia ; Cotorruelo, Carlos ; Biondi, Claudia. Secretor status and ABH antigens expression in patients with oral lesions. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 12 6 2007: 4- es
dc.identifier.uri http://hdl.handle.net/10550/63154
dc.description.abstract Objectives: The aim of this work was to investigate the secretor status of patients with oral pre-cancerous and cancerous lesions and ABH antigens expression in fixed tissue sections of these patients. Study design: To reveal A, B and H antigens in tissue sections of patients with precancerous and cancerous oral lesions (n= 54) we used a modified specific red cell adherence technique (SRCA-test). Normal endothelial cells expressed ABH antigens, the presence of indicator erythrocytes at the lumen of the blood vessels served as a built in positive control. The test results were graded from negative adherence to very strongly positive adherence. Negative adherence was defined as a complete absence of adhered indicator erythrocytes. A strongly positive reaction was defined as a sheet of indicator erythrocytes adhered to the epithelia cells. Results: In 31 of the 54 samples analyzed the test showed slightly positive results on atypical areas, and there was a complete antigen deletion in areas histologically affected by neoplasia. Sixteen samples showed a total absence of ABH antigens in both histologically normal and pathological areas. As a working hypothesis, we propose that areas of SRCA-test negative epithelium are closely related to invasive carcinomas and may be their precursor lesions. Further it is suggested that areas of blood group isoantigen negative epithelium showing atypia, or in some instances near normal histology, may give rise to relatively low grade carcinomas. Conclusions: Considering these results we suggest the use of this method to monitor probable preneoplastic lesions in risk population, specially in those with no secretor status. es
dc.title Secretor status and ABH antigens expression in patients with oral lesions es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es
dc.type.hasVersion VoR es_ES

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