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pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia

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pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia

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dc.contributor.author Rojas de Morales, Thais es
dc.contributor.author Navas, Rita es
dc.contributor.author Viera, Ninoska es
dc.contributor.author Álvarez, Carmen es
dc.contributor.author Chaparro, Neira es
dc.contributor.author Griman, Dariana es
dc.date.accessioned 2017-11-20T12:32:07Z
dc.date.available 2017-11-20T12:32:07Z
dc.date.issued 2007 es
dc.identifier.citation Rojas de Morales, Thais ; Navas, Rita ; Viera, Ninoska ; Álvarez, Carmen ; Chaparro, Neira ; Griman, Dariana. pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 12 6 2007: 5- es
dc.identifier.uri http://hdl.handle.net/10550/63155
dc.description.abstract Objective: To analyze the behavior of pH and sodium bicarbonate (NAHCO3) in the saliva of patients with leukemia during the administration protocol for Methotrexate (Mtx). Materials and Methods: A controlled clinical essay was carried out on 23 patients between 4 and 18 years of age with high-risk Acute Lymphoblastic Leukemia. Sampling was carried out at To : basal condition; T1 : 12 hours after intravenous administration of sodium bicarbonate, before administering Mtx and T2 : 3 hours after administering Mtx, the time of maximum concentration. Chiron-Diagnostic 378® equipment was used to determine pH and sodium bicarbonate. The data was interpreted using Analysis of Variance at the 5% significance level. Results: The highest values of sodium bicarbonate were observed at T2 , with salivary pH levels remaining within neutrality ranges, diminishing slightly in T1 . Conclusion. In this study, the dose of sodium bicarbonate considered in the administration protocol of 3 g /m2 Mtx, kept sodium bicarbonate levels in saliva at normal levels and pH neutral. es
dc.title pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es
dc.type.hasVersion VoR es_ES

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