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Synthesis and antibacterial activities of cadiolides A, B and C and analogues

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Synthesis and antibacterial activities of cadiolides A, B and C and analogues

dc.contributor.author	Boulangé, Agathe
dc.contributor.author	Párraga Vidal, Javier
dc.contributor.author	Galán Morant, Abraham
dc.contributor.author	Cabedo Escrig, Nuria
dc.contributor.author	Leleu, Stéphane
dc.contributor.author	Sanz Ferrando, María Jesús
dc.contributor.author	Cortés Martínez, Diego M.
dc.contributor.author	Franck, Xavier
dc.date.accessioned	2017-11-20T13:48:53Z
dc.date.available	2017-11-20T13:48:53Z
dc.date.issued	2015
dc.identifier.citation	Boulangé, Agathe Párraga Vidal, Javier Galán Morant, Abraham Cabedo Escrig, Nuria Leleu, Stéphane Sanz Ferrando, María Jesús Cortés Martínez, Diego M. Franck, Xavier 2015 Synthesis and antibacterial activities of cadiolides A, B and C and analogues Bioorganic & Medicinal Chemistry 23 13 3618 3628
dc.identifier.uri	http://hdl.handle.net/10550/63166
dc.description.abstract	The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.
dc.language.iso	eng
dc.relation.ispartof	Bioorganic & Medicinal Chemistry, 2015, vol. 23, num. 13, p. 3618-3628
dc.subject	Farmacologia
dc.subject	Compostos orgànics Síntesi
dc.title	Synthesis and antibacterial activities of cadiolides A, B and C and analogues
dc.type	journal article	es_ES
dc.date.updated	2017-11-20T13:48:54Z
dc.identifier.doi	10.1016/j.bmc.2015.04.010
dc.identifier.idgrec	108909
dc.rights.accessRights	open access	es_ES