NAGIOS: RODERIC FUNCIONANDO

Identification of Bioactive Compounds in Polar and Nonpolar Extracts of Araujia sericifera

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Identification of Bioactive Compounds in Polar and Nonpolar Extracts of Araujia sericifera

dc.contributor.author	Palomino-Schätzlein, Martina
dc.contributor.author	Montaño, Mary Cecilia
dc.contributor.author	Escrig, Pablo V.
dc.contributor.author	Boira, Herminio
dc.contributor.author	Corma, Avelino
dc.contributor.author	Pineda Lucena, Antonio
dc.contributor.author	Primo, Jaime
dc.contributor.author	Cabedo Escrig, Nuria
dc.date.accessioned	2017-11-20T15:33:23Z
dc.date.available	2017-11-20T15:33:23Z
dc.date.issued	2017
dc.identifier.citation	Palomino-Schätzlein, Martina Montaño, Mary Cecilia Escrig, Pablo V. Boira, Herminio Corma, Avelino Pineda Lucena, Antonio Primo, Jaime Cabedo Escrig, Nuria 2017 Identification of Bioactive Compounds in Polar and Nonpolar Extracts of Araujia sericifera Planta Medica International Open 4 93 103
dc.identifier.uri	http://hdl.handle.net/10550/63169
dc.description.abstract	Araujia sericifera is a native perennial, climbing laticiferous shrub from South America that is currently naturalized in many other countries. Previous data describe promising properties for A. sericifera, but no systematic study of its bioactive compounds and possible medicinal applications has been conducted to date. In the present study, aerial parts of A. sericifera (leaves, stems, and fruits) were explored by combining GC-MS and NMR spectroscopy analysis for both nonpolar (hexane) and polar (methanol) extracts. The hexanic extracts contained high amounts of pentacyclic triterpenes including two new metabolites, 3-tigloyl germanicol (18) and 3-tigloyl lupeol (19). The methanolic extracts revealed the presence of luteolin-7-glucoside (24), trigonelline (22), and conduritol F (23) as the main constituents. A multivariate study of a meaningful number of extracts allowed us to determine the distribution of compounds inside the plant. A cytotoxic evaluation in vitro showed that both leaf and fruit hexanic extracts presented a moderate activity against human breast carcinoma cell lines (MDA-MB-453 and MCF-7) and human colon carcinoma cell line (HCT-116) by the MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay.
dc.language.iso	eng
dc.relation.ispartof	Planta Medica International Open, 2017, vol. 4, p. 93-103
dc.subject	Plantes medicinals
dc.subject	Química agrícola
dc.title	Identification of Bioactive Compounds in Polar and Nonpolar Extracts of Araujia sericifera
dc.type	journal article	es_ES
dc.date.updated	2017-11-20T15:33:23Z
dc.identifier.doi	10.1055/s-0043-121151
dc.identifier.idgrec	121082
dc.rights.accessRights	open access	es_ES