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Osteonecrosis of the jaw as an adverse bisphosphonate event : Three cases of bone metastatic prostate cancer patients treated with zoledronic acid

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Osteonecrosis of the jaw as an adverse bisphosphonate event : Three cases of bone metastatic prostate cancer patients treated with zoledronic acid

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dc.contributor.author García Sáenz, José Ángel es
dc.contributor.author López-Tarruella Cobo, Sara es
dc.contributor.author García Paredes, Beatriz es
dc.contributor.author Rodríguez Lajusticia, Laura es
dc.contributor.author Villalobos León, María Laura es
dc.contributor.author Díaz-Rubio García, Eduardo es
dc.date.accessioned 2017-11-21T10:50:23Z
dc.date.available 2017-11-21T10:50:23Z
dc.date.issued 2007 es
dc.identifier.citation García Sáenz, José Ángel ; López-Tarruella Cobo, Sara ; García Paredes, Beatriz ; Rodríguez Lajusticia, Laura ; Villalobos León, María Laura ; Díaz-Rubio García, Eduardo. Osteonecrosis of the jaw as an adverse bisphosphonate event : Three cases of bone metastatic prostate cancer patients treated with zoledronic acid. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 12 5 2007: 4- es
dc.identifier.uri http://hdl.handle.net/10550/63188
dc.description.abstract Bisphosphonates offer a significant improvement in the quality of life for cancer patients; these potent inhibitors of bone resorption have been shown to markedly reduce the morbidity frequently resulting from bone metastases. Despite the success of bisphosphonates as therapeutic agents, however, toxicity in the form of osteonecrosis of the jaw (ONJ) is a rare complication whose incidence rate has climbed in recent years. ONJ is defined as an unexpected development of necrotic bone in the oral cavity, and is commonly associated with administration of the bisphosphonates Pamidronate and Zoledronate. Clinical features include local pain, soft-tissue swelling, and/or loose teeth; ONJ is also often correlated with previous dental procedures, such as tooth extractions, during biphosphonate therapy. Although additional risk factors--such as corticosteroids, chemotherapy, radiotherapy, trauma or infection?exhibit etiological associations with ONJ, the real pathobiology has not yet been fully elucidated. Here we report our findings on all 2005 OJN cases presented at our institution resulting from bone metastatic prostate cancer treated with zoledronic acid. The incidence of ONJ is nearly 3% (3 out of 104) in these patients. es
dc.title Osteonecrosis of the jaw as an adverse bisphosphonate event : Three cases of bone metastatic prostate cancer patients treated with zoledronic acid es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es
dc.type.hasVersion VoR es_ES

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