NAGIOS: RODERIC FUNCIONANDO

Diagnostic efficacy of sentinel node biopsy in oral squamous cell carcinoma : cohort study and meta-analysis

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Diagnostic efficacy of sentinel node biopsy in oral squamous cell carcinoma : cohort study and meta-analysis

dc.contributor.author	Álvarez Amezaga, Julio	es
dc.contributor.author	Barbier Herrero, Luis	es
dc.contributor.author	Pijoan Zubizarreta, J.I.	es
dc.contributor.author	Martín Rodríguez, Jesús Carmelo	es
dc.contributor.author	Romo Simón, Laura	es
dc.contributor.author	Genollá Subirats, Jose	es
dc.contributor.author	Ríos Altolaguirre, Gonzalo	es
dc.contributor.author	Ríos, Antonio de los	es
dc.contributor.author	Arteagoitia Calvo, María Iciar	es
dc.contributor.author	Landa Llona, Salvador	es
dc.contributor.author	Arruti, J.A.	es
dc.contributor.author	López-Cedrún Cembranos, José Luis	es
dc.contributor.author	Santamaría Zuazua, Joseba Andoni	es
dc.date.accessioned	2017-11-22T09:31:46Z
dc.date.available	2017-11-22T09:31:46Z
dc.date.issued	2007	es
dc.identifier.citation	Álvarez Amezaga, Julio ; Barbier Herrero, Luis ; Pijoan Zubizarreta, J.I. ; Martín Rodríguez, Jesús Carmelo ; Romo Simón, Laura ; Genollá Subirats, Jose ; Ríos Altolaguirre, Gonzalo ; Ríos, Antonio de los ; Arteagoitia Calvo, María Iciar ; Landa Llona, Salvador ; Arruti, J.A. ; López-Cedrún Cembranos, José Luis ; Santamaría Zuazua, Joseba Andoni. Diagnostic efficacy of sentinel node biopsy in oral squamous cell carcinoma : cohort study and meta-analysis. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 12 3 2007: 14-	es
dc.identifier.uri	http://hdl.handle.net/10550/63243
dc.description.abstract	Objectives: To evaluate the efficacy of sentinel node biopsy (SNB) in oral squamous cell carcinoma (OSCC). Design: A prospective study of a cohort of 25 consecutive patients with OSCC anatomopathological confirmation through biopsy, without oncological pre-treatment, in clinical stage T1-T4N0, of these 25 patients 14 were T1-T2N0. The absence of regional disease (N0) was determined by means of clinical exploration and cervical tomography (CT). To establish the overall sensitivity of the technique, a meta-analysis was carried out of 10 series published to February 2005 where SNB had been applied to head and neck cancer, adding our 14 T1-T2N0 cases, thus making a total of 260 patients. Results: Identification by SNB was accurate in 96% of the 25 cases, with a sensitivity of 66.7%. Analyzing only the T1-T2N0 cases (n=14), the accuracy was 100% with a sensitivity of 1 (CI 95%, 0.29-1.00). The overall sensitivity was 93%. The accuracy in identifying the sentinel node varied between 66% and 100%. The SN was identified in 251 of 260 cases, of those, 71 were true positive, 5 false negative and 175 true negative. The overall sensitivity was 93.4% (CI 95%, 85.3-97.8), with a specificity of 100% (CI 95%, 0.98-100). The weighted negative probability quotient was 0.176 (CI 0.103-0.301) and that of positive probability 24.75 (CI 95%, 10.8-56.71). The weighted diagnostic odds ratio was 183.71 (CI 95%, 59.36-568.56). If we accept that the prevalence of hidden regional disease is 30%, a negative sentinel node has 5% possibility of having hidden disease. Conclusions: Our data provide a certain degree of evidence that, due to its high sensitivity, the SNB procedure can be applied to the initial stages of OSCC.	es
dc.title	Diagnostic efficacy of sentinel node biopsy in oral squamous cell carcinoma : cohort study and meta-analysis	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi		es
dc.type.hasVersion	VoR	es_ES