The healing of xenograft augmentated intra-alveolar gaps following immediate implant placement (IMIP) after tooth extraction is likely to differ in time and density compared to the native bone part that directly contacts the implant. Secondary implant stability (SIS) data recorded 2-3 months following a late implant placement protocol (LIP) (n= 43) and 6-8 months following an immediate implant placement protocol (IMIP) (n=33) of variable-thread implants (Nobel Active?) in the maxilla were retrospectively collected from files of 63 patients (42 females, 21 males). Statistical analysis was performed using a generalized estimating equation model (GEE). Data split-up according to implant diameter (RP, Ø= 4.3mm) , narrow platform (NP, Ø= 3.5mm) was adopted. For NP implants, the mean ISQ (±SD) values were 70.84 (±4.86) in LIP group and 72.41 (±3.89) in the IMIP group. For RP implants, mean ISQ (±SD) values were 73.45 (±8.77) in the LIP group and 75.93 (±5.73) in the IMIP group. Significant effect of treatment modus in favour of the IMIP and gender in favour of males and implant position was noted (p<0.05). SIS following a IMIP protocol after 6-8 months is comparable to LIP protocol after 2-3 months. A minor ISQ outcome difference in favour of the IMIP protocol can be attributed to a difference in hard tissue alteration during healing of the xenograft part.