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Asymmetric cell division requires specific mechanisms for adjusting global transcription

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Asymmetric cell division requires specific mechanisms for adjusting global transcription

dc.contributor.author	Mena, Adriana
dc.contributor.author	Medina Salas, Daniel Alejandro
dc.contributor.author	García Martínez, José
dc.contributor.author	Begley, Victoria
dc.contributor.author	Singh, Abhyudai
dc.contributor.author	Chávez, Sebastián
dc.contributor.author	Muñoz-Centeno, María de la Cruz
dc.contributor.author	Pérez Ortín, José Enrique
dc.date.accessioned	2017-12-11T15:46:32Z
dc.date.available	2017-12-11T15:46:32Z
dc.date.issued	2017
dc.identifier.citation	Mena, Adriana Medina Salas, Daniel Alejandro García Martínez, José Begley, Victoria Singh, Abhyudai Chávez, Sebastián Muñoz-Centeno, María de la Cruz Pérez Ortín, José Enrique 2017 Asymmetric cell division requires specific mechanisms for adjusting global transcription Nucleic Acids Research 45 21 12401 12412
dc.identifier.uri	http://hdl.handle.net/10550/63530
dc.description.abstract	Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric cell division that can generate sibling cell size differences. Whereas physical asymmetric division mechanisms and cell fate consequences have been investigated, the specific problem caused by asymmetric division at the transcription level has not yet been addressed. In symmetrically dividing cells the nascent transcription rate increases in parallel to cell volume to compensate it by keeping the actual mRNA synthesis rate constant. This cannot apply to the yeast Saccharomyces cerevisiae, where this mechanism would provoke a never-ending increasing mRNA synthesis rate in smaller daughter cells. We show here that, contrarily to other eukaryotes with symmetric division, budding yeast keeps the nascent transcription rates of its RNA polymerases constant and increases mRNA stability. This control on RNA pol II-dependent transcription rate is obtained by controlling the cellular concentration of this enzyme.
dc.language.iso	eng
dc.relation.ispartof	Nucleic Acids Research, 2017, vol. 45, num. 21, p. 12401-12412
dc.subject	Cèl·lules Divisió
dc.subject	Biotecnologia
dc.title	Asymmetric cell division requires specific mechanisms for adjusting global transcription
dc.type	journal article	es_ES
dc.date.updated	2017-12-11T15:46:33Z
dc.identifier.doi	10.1093/nar/gkx974
dc.identifier.idgrec	121511
dc.rights.accessRights	open access	es_ES