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A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

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A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

dc.contributor.author	Pleguezuelos-Villa, María
dc.contributor.author	Mir-Palomo, Silvia
dc.contributor.author	Díez Sales, Octavio
dc.contributor.author	Vila Busó, M. A. Ofelia
dc.contributor.author	Ruiz Saurí, Amparo
dc.contributor.author	Nácher Alonso, Amparo
dc.date.accessioned	2017-12-15T15:18:52Z
dc.date.available	2017-12-15T15:18:52Z
dc.date.issued	2018
dc.identifier.citation	Pleguezuelos-Villa, María Mir-Palomo, Silvia Díez Sales, Octavio Vila Buso, M. A. Ofelia Ruiz Saurí, Amparo Nácher Alonso, Amparo 2017 A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy Colloids and Surfaces B-Biointerfaces 1 36
dc.identifier.uri	http://hdl.handle.net/10550/63632
dc.description.abstract	Ultradeformable liposomes were formulated using naringin (NA), a flavanone glycoside, at different concentrations (3,6 and 9 mg/mL). Nanovesicles were small size (∼100 nm), regardless of the NA concentration used, and monodisperse (PI < 0.30). All formulations showed a high entrapment efficiency (∼88%) and a highly negative zeta potential (around −30 mV). The selected formulations were highly biocompatible as confirmed by in vitro studies using 3T3 fibroblasts. In vitro assay showed that the amounts (%) of NA accumulated in the epidermis (∼10%) could explain the anti-inflammatory properties of ultradeformable liposomes. In vivo studies confirmed the higher effectiveness of ultradeformable liposomes respect to betamethasone cream and NA dispersion in reducing skin inflammation in mice. Overall, it can conclude that NA ultradeformable liposomes can be considered as a promising formulation for the treatment of skin inflammatory diseases.
dc.language.iso	eng
dc.relation.ispartof	Colloids and Surfaces B-Biointerfaces, 2017, p. 1-36
dc.subject	Pell
dc.subject	Antiinflamatoris
dc.title	A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy
dc.type	journal article	es_ES
dc.date.updated	2017-12-15T15:18:53Z
dc.identifier.doi	10.1016/j.colsurfb.2017.11.068
dc.identifier.idgrec	121775
dc.rights.accessRights	open access	es_ES