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Progressive rise of c fos expression from premalignant to malignant lesions of oral cavity

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Progressive rise of c fos expression from premalignant to malignant lesions of oral cavity

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dc.contributor.author Sachdev, Ritesh es
dc.contributor.author Mandal, Ashish Kumar es
dc.contributor.author Singh, Ishwar es
dc.contributor.author Agarwal, Arun Kumar es
dc.date.accessioned 2017-12-16T08:23:52Z
dc.date.available 2017-12-16T08:23:52Z
dc.date.issued 2008 es
dc.identifier.citation Sachdev, Ritesh ; Mandal, Ashish Kumar ; Singh, Ishwar ; Agarwal, Arun Kumar. Progressive rise of c fos expression from premalignant to malignant lesions of oral cavity. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 13 11 2008: 2- es
dc.identifier.uri http://hdl.handle.net/10550/63635
dc.description.abstract Objectives: Oral cancer is a worldwide phenomenon. It is thought to develop in a number of premalignant lesions. Protooncogene c fos is a known transformer of premalignant to malignant lesions. However, its role in oral carcinogenesis is not yet known. Study design: A total of 130 cases were studied comprising of premalignant lesions (n=50), squamous cell carcinoma (n=50) and controls (n=30). c fos expression was studied by immunohistochemistry. Results: Premalignant lesions of oral cavity occurred at a lower age group (mean 39.2 years) compared to squamous cell carcinoma (mean 51.8 years), p <0.001. Mean c fos percentage positivity in squamous cell carcinomas (SCC), premalignant lesions and controls was 44.5±36.9%, 11.4±18.8% and 1.23±2.6% respectively, the differences were highly significant (p<0.001). c fos positivity also increased from mild (10.85±14.23%) to moderate dysplasia (19.64 ±26.05%). Conclusions: The serially increasing c fos expression from normal mucosa to premalignant lesions to SCC and in dysplasias suggests that it could be an early gene to get activated and form transcription factor activator protein ?1(AP-1). es
dc.title Progressive rise of c fos expression from premalignant to malignant lesions of oral cavity es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi es
dc.type.hasVersion VoR es_ES

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