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Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of burning mouth syndrome : a randomized, double-blind, placebo controlled trial

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Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of burning mouth syndrome : a randomized, double-blind, placebo controlled trial

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dc.contributor.author López D'alessandro, Edgardo es
dc.contributor.author Escovich, Livia es
dc.date.accessioned 2017-12-16T12:10:09Z
dc.date.available 2017-12-16T12:10:09Z
dc.date.issued 2011 es
dc.identifier.citation López D'alessandro, Edgardo ; Escovich, Livia. Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of burning mouth syndrome : a randomized, double-blind, placebo controlled trial. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 16 5 2011: 1- es
dc.identifier.uri http://hdl.handle.net/10550/63677
dc.description.abstract Burning Mouth Syndrome (BMS) is a disease that manifests as burning in the tongue or in any area of the oral mucosa, in the absence of clinically verifiable injuries. Objectives: To verify the efficacy of alpha lipoic acid (ALA) and gabapentin (GABA), used individually and jointly, to reduce the burning in patients with burning mouth and establish a drug therapy for the BMS. Study Design: During April and May 2008, we conducted a randomized, double-blind, placebo-controlled trial in the Department of Clinical Stomatology, Faculty of Dentistry, Rosario, Argentina. The gathering of patients was between those ones with BMS who were treated in our service between March 2003 and March 2008 without complying with the applied treatments. The 120 patients were randomly divided into 4 groups and were provided, by lot and in a blinded fashion, with four different treatment cycles consisting of the following drugs: Group A (n = 20) 600 mg/day of alpha lipoic acid for two months, Group B (n = 20) 300 mg/day of gabapentin for two months, Group C (n = 20) a combination of both drugs for two months and Group D (n = 60) 100 mg/day of ce-llulose starch for two months (control group). Results and Conclusions: All 120 patients completed the treatment. The best response was obtained with the combination of ALA + GABA, with a 70% of the cases with reduced burning in this group and a 13.2 times greater chance of presenting positive changes for these patients than those taking placebo. The combined use of drugs that act at different levels of the nociceptive system can be useful for the treatment of this syndrome. © Medicina Oral. es
dc.title Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of burning mouth syndrome : a randomized, double-blind, placebo controlled trial es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.16942 es
dc.type.hasVersion VoR es_ES

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