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Enantioselective transformation of fluoxetine in water and its ecotoxicological relevance

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Enantioselective transformation of fluoxetine in water and its ecotoxicological relevance

dc.contributor.author	Andrés-Costa, Maria-Jesús
dc.contributor.author	Proctor, Kathryn
dc.contributor.author	Sabatini, Marco T.
dc.contributor.author	Gee, Anthony P.
dc.contributor.author	Lewis, Simon E.
dc.contributor.author	Picó García, Yolanda
dc.contributor.author	Kasprzyk-Hordern, Barbara
dc.date.accessioned	2017-12-21T18:29:21Z
dc.date.available	2017-12-21T18:29:21Z
dc.date.issued	2017
dc.identifier.citation	Andrés-Costa, Maria-Jesús Proctor, Kathryn Sabatini, Marco T. Gee, Anthony P. Lewis, Simon E. Picó García, Yolanda Kasprzyk-Hordern, Barbara 2017 Enantioselective transformation of fluoxetine in water and its ecotoxicological relevance Scientific Reports 7 (1) 15777-1 15777-13
dc.identifier.uri	http://hdl.handle.net/10550/63755
dc.description.abstract	European legislation focusing on water quality is expected to broaden to encompass several pharmaceuticals as priority hazardous substances. This manuscript aims to challenge current regulatory approaches that do not recognize stereochemistry of chiral pharmaceuticals by testing the hypothesis that environmental transformation and effects of chiral pharmaceuticals are stereoselective. Our experiments revealed that, while degradation of chiral fluoxetine (FL) in river water occurs via non-enantioselective photochemical and mildly-enantioselective microbial processes favoring the (R)-enantiomer, a pronounced enantioselectivity favoring (S)-FL (leading to the formation of (S)-NFL (norfluoxetine)) is observed during activated sludge treatment. Toxicity tests proved strong enantiomer-specific toxicity in the case of Tetrahymena thermophila, protozoa that are utilized during activated sludge treatment ((R)-FL is 30× more toxic than (S)-FL; (S)-NFL is 10× more toxic than (S)-FL). This is of paramount importance as preferential degradation of (S)-FL in activated sludge microcosms leads to the enrichment of FL with 30× more toxic (R)-FL and formation of 10× more toxic (S)-NFL. It is commonly assumed that a decreased concentration of FL leads to decreased biological impact. Our study proves that despite the overall decrease in FL concentration, accumulation of toxic (R)-FL and formation of toxic (S)-NFL leads to much higher than presumed toxicological effects.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2017, vol. 7 (1), p. 15777-1-15777-13
dc.subject	Aigua Contaminació
dc.subject	Medi ambient Anàlisi d'impacte
dc.subject	Toxicologia ambiental
dc.title	Enantioselective transformation of fluoxetine in water and its ecotoxicological relevance
dc.type	journal article	es_ES
dc.date.updated	2017-12-21T18:29:21Z
dc.identifier.doi	10.1038/s41598-017-15585-1
dc.identifier.idgrec	121162
dc.rights.accessRights	open access	es_ES