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Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

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Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

dc.contributor.author	Catalán Latorre, Ana
dc.contributor.author	Pleguezuelos-Villa, María
dc.contributor.author	Castangia, Ines
dc.contributor.author	Manca, Maria Letizia
dc.contributor.author	Caddeo, Carla
dc.contributor.author	Nácher Alonso, Amparo
dc.contributor.author	Díez Sales, Octavio
dc.contributor.author	Peris Ribera, José Esteban
dc.contributor.author	Pons, Ramon
dc.contributor.author	Escribano-Ferrer, Elvira
dc.contributor.author	Fadda, Anna Maria
dc.contributor.author	Manconi, Maria
dc.date.accessioned	2018-01-17T14:37:28Z
dc.date.available	2018-12-14T05:45:04Z
dc.date.issued	2017
dc.identifier.citation	Catalán Latorre, Ana Pleguezuelos-Villa, María Castangia, Ines Manca, Maria Letizia Caddeo, Carla Nácher Alonso, Amparo Díez Sales, Octavio Peris Ribera, José Esteban Pons, Ramon Escribano-Ferrer, Elvira Fadda, Anna Maria Manconi, Maria 2017 Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation Nanoscale 1 36
dc.identifier.uri	http://hdl.handle.net/10550/64016
dc.description.abstract	Nutriosomes, new phospholipid nanovesicles specifically designed for intestinal protection were developed by simultaneously loading a water-soluble dextrine (Nutriose® FM06) and a natural antioxidant (curcumin). Nutriosomes were easily fabricated in a one-step, organic solvent-free procedure. The stability and the delivery performances of the vesicles were improved by adding hydroxypropylmetylcellulose. All the vesicles were small in size (mean diameter ~168 nm), negatively charged (zeta potential ~-38 mV, irrespective of their composition), self-assembled predominantly in unilamellar vesicles stabilized by the presence of Nutriose® , which was located in both the inter-lamellar and inter-vesicle medium, as confirmed by cryo-TEM and SAXS investigation. The dextrin acted also as a cryo-protector, avoiding vesicle collapse during the lyophilization process, and as a protector against high ionic strength and pH changes encountered in the gastrointestinal environment. Thanks to the antioxidant properties of curcumin, nutriosomes provided an optimal protective effect against hydrogen peroxide-induced oxidative stress in Caco-2 cells. Moreover, these innovative vesicles showed promising efficacy in vivo, as they improved the bioavailability and the biodistribution of both curcumin and dextrin upon oral administration, which acted synergically in reducing colonic damage chemically-induced in rats.
dc.language.iso	eng
dc.relation.ispartof	Nanoscale, 2017, p. 1-36
dc.subject	Antioxidants
dc.subject	Estrès oxidatiu
dc.title	Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation
dc.type	journal article	es_ES
dc.date.updated	2018-01-17T14:37:28Z
dc.identifier.doi	10.1039/C7NR05929A
dc.identifier.idgrec	121774
dc.embargo.terms	1 year
dc.rights.accessRights	open access	es_ES