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VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy

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VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy

dc.contributor.author	Juanes, José M.
dc.contributor.author	Gallego, Asunción
dc.contributor.author	Tárraga, Joaquín
dc.contributor.author	Chaves Martínez, Felipe Javier
dc.contributor.author	Marín-Garcia, Pablo
dc.contributor.author	Medina, Ignacio
dc.contributor.author	Arnau Llombart, Vicente
dc.contributor.author	Dopazo Blázquez, Joaquín
dc.date.accessioned	2018-03-28T17:35:29Z
dc.date.available	2018-03-28T17:35:29Z
dc.date.issued	2017
dc.identifier.citation	Juanes, José M. Gallego, Asunción Tárraga, Joaquín Chaves Martínez, Felipe Javier Marín-Garcia, Pablo Medina, Ignacio Arnau Llombart, Vicente Dopazo Blázquez, Joaquín 2017 VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy Bmc Bioinformatics 18:421
dc.identifier.uri	http://hdl.handle.net/10550/65532
dc.description.abstract	Background -- The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefore, the analysis of integration sites of retroviral vectors is a crucial step in developing safer vectors for therapeutic use. Results -- Here we present VISMapper, a vector integration site analysis web server, to analyze next-generation sequencing data for retroviral vector integration sites. VISMapper can be found at: http://vismapper.babelomics.org. Conclusions -- Because it uses novel mapping algorithms VISMapper is remarkably faster than previous available programs. It also provides a useful graphical interface to analyze the integration sites found in the genomic context.
dc.language.iso	eng
dc.relation.ispartof	Bmc Bioinformatics, 2017, vol. 18:421
dc.subject	gens mapatge
dc.subject	genoma humà
dc.title	VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy
dc.type	journal article	es_ES
dc.date.updated	2018-03-28T17:35:29Z
dc.identifier.doi	10.1186/s12859-017-1837-z
dc.identifier.idgrec	124399
dc.rights.accessRights	open access	es_ES