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Activation of bee venom phospholipase A2 through a peptide-enzyme complex

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Activation of bee venom phospholipase A2 through a peptide-enzyme complex

dc.contributor.author	Mingarro Muñoz, Ismael
dc.contributor.author	Pérez Payá, Enrique
dc.contributor.author	Pinilla, Clemencia
dc.contributor.author	Appel, Jon R.
dc.contributor.author	Houghten, Richard A.
dc.contributor.author	Blondelle, Sylvie E.
dc.date.accessioned	2018-04-13T14:44:30Z
dc.date.available	2018-04-13T14:44:30Z
dc.date.issued	1995
dc.identifier.citation	Mingarro Muñoz, Ismael Pérez Payá, Enrique Pinilla, Clemencia Appel, Jon R. Houghten, Richard A. Blondelle, Sylvie E. 1995 Activation of bee venom phospholipase A2 through a peptide-enzyme complex Febs Letters 372 1 131 134
dc.identifier.uri	http://hdl.handle.net/10550/65665
dc.description.abstract	Phospholipase A2 activation by membrane‐bound peptides was investigated in order to understand the role of the membrane‐induced conformation on activation, and to examine the occurrence of a peptide‐enzyme complex at the lipid/water interface. For the peptides studies, bee venom phospholipase A2 was stimulated regardless of the membrane‐bound conformation (α‐helix, β‐sheet or random coil). Using antisera raised against melittin, we were able to demonstrate the occurrence of a calcium‐dependent complex involving the enzyme, phospholipid substrate, and peptide.
dc.language.iso	eng
dc.relation.ispartof	Febs Letters, 1995, vol. 372, num. 1, p. 131-134
dc.subject	Pèptids
dc.subject	Abelles
dc.title	Activation of bee venom phospholipase A2 through a peptide-enzyme complex
dc.type	journal article	es_ES
dc.date.updated	2018-04-13T14:44:30Z
dc.identifier.doi	10.1016/0014-5793(95)00964-B
dc.identifier.idgrec	008447
dc.rights.accessRights	open access	es_ES