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1p36 deletion results in a decrease in glycosaminoglycans which is associated with aggressiveness in neuroblastic tumors.

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1p36 deletion results in a decrease in glycosaminoglycans which is associated with aggressiveness in neuroblastic tumors.

dc.contributor.author	Tadeo Cervera, Irene
dc.contributor.author	Gamero Sandemetrio, Esther
dc.contributor.author	Berbegall Beltrán, Ana Pilar Pilar
dc.contributor.author	Navarro Fos, Samuel
dc.contributor.author	Cañete Nieto, Adela
dc.contributor.author	Noguera Salvá, Rosa
dc.date.accessioned	2018-04-16T07:24:53Z
dc.date.available	2018-04-16T07:24:53Z
dc.date.issued	2018
dc.identifier.citation	Tadeo Cervera, Irene Gamero Sandemetrio, Esther Berbegall Beltrán, Ana Pilar Pilar Navarro Fos, Samuel Cañete Nieto, Adela Noguera Salvá, Rosa 2018 1p36 deletion results in a decrease in glycosaminoglycans which is associated with aggressiveness in neuroblastic tumors. Histology and Histopathology 33 487 495
dc.identifier.uri	http://hdl.handle.net/10550/65671
dc.description.abstract	Despite our deep understanding of neuroblastic tumors, some patients still suffer treatment failure, so pre-treatment risk stratification still requires improvement and the search for new therapeutic targets must continue. Here we correlated prognostic clinical and biological features of neuroblastic tumors with the density of extracellular matrix glycosaminoglycans (the main components of the extracellular matrix 'ground substance'), in nearly 400 primary samples. We also studied the relationship between the density of extracellular matrix glycosaminoglycans and the expression of B3GALT6, an enzyme required for their synthesis. We associated a decrease in glycosaminoglycans with neuroblastomas that were histopathologically poorly-differentiated or undifferentiated, as well as with metastatic disease, and 1p36 deleted tumors. This decrease in glycosaminoglycans was also related to abnormal nuclear B3GALT6 expression in neuroblastic cells. These findings point towards the importance of the ground substance in the aggressiveness of neuroblastic tumors, which should therefore be considered when developing novel therapies for treating neuroblastomas.
dc.language.iso	eng
dc.relation.ispartof	Histology and Histopathology, 2018, vol. 33, p. 487-495
dc.subject	Histologia
dc.subject	Tumors
dc.title	1p36 deletion results in a decrease in glycosaminoglycans which is associated with aggressiveness in neuroblastic tumors.
dc.type	journal article	es_ES
dc.date.updated	2018-04-16T07:24:53Z
dc.identifier.doi	10.14670/HH-11-947
dc.identifier.idgrec	122161
dc.rights.accessRights	open access	es_ES