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Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion

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Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion

dc.contributor.author	Gómara, María J.
dc.contributor.author	Lorizate, Maier
dc.contributor.author	Huarte, Nerea
dc.contributor.author	Mingarro Muñoz, Ismael
dc.contributor.author	Pérez Payá, Enrique
dc.contributor.author	Nieva, José Luis
dc.date.accessioned	2018-04-16T13:45:07Z
dc.date.available	2018-04-16T13:45:07Z
dc.date.issued	2006
dc.identifier.citation	Gómara, María J. Lorizate, Maier Huarte, Nerea Mingarro Muñoz, Ismael Pérez Payá, Enrique Nieva, José Luis 2006 Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion Febs Letters 580 11 2561 2566
dc.identifier.uri	http://hdl.handle.net/10550/65693
dc.description.abstract	Upon receptor-mediated activation, the gp41 hydrophobic, conserved fusion peptide inserts into the target mem- brane and promotes the kind of perturbations required for the progression of the HIV-cell fusion reaction. Using a synthetic combinatorial library we have identified all D-amino acid hexapeptide sequences that inhibited the fusion peptide capacity of perturbing model membranes. Two hexapeptides that effectively inhibited the fusion peptide in these systems were subsequently shown to inhibit cell-cell fusion promoted by gp41 expressed at cell surfaces. These observations might be of importance for understanding the mechanisms underlying fusion peptide activity and suggest new strategies for screening compounds that target these viral sequences.
dc.language.iso	eng
dc.relation.ispartof	Febs Letters, 2006, vol. 580, num. 11, p. 2561-2566
dc.subject	Membranes (Biologia)
dc.subject	Pèptids
dc.title	Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion
dc.type	journal article	es_ES
dc.date.updated	2018-04-16T13:45:07Z
dc.identifier.doi	10.1016/j.febslet.2006.04.003
dc.identifier.idgrec	027417
dc.rights.accessRights	open access	es_ES