NAGIOS: RODERIC FUNCIONANDO

Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein

Repositori DSpace/Manakin

Valencià Castellano

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein

Mostra el registre complet de l'element

Visualització (160.1Kb)

Gómara, María J.; Mora, Puig; Mingarro Muñoz, Ismael; Nieva, José Luis

Aquest document és un/a article, creat/da en: 2004

The structural determinants underlying the functionality of viral internal fusion peptides (IFPs) are not well understood. We have compared EBOwt (GAAIGLAWIPY- FGPAAE), representing the IFP of the Ebola fusion protein GP, and EBOmut (GAAIGLAWIPYFGRAAE) derived from a non-functional mutant with conserved Pro537 substituted by Arg. P537R substitution did not abrogate peptide-membrane association, but interfered with the ability to induce bilayer destabilization. Structural determinations suggest that Pro537 is required to preserve a membrane-perturbing local conformation in apolar environments.

Veure al catàleg Trobes