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Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva

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Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva

dc.contributor.author	López-Verdín, Sandra	es
dc.contributor.author	Soto-Avila, Juan-José	es
dc.contributor.author	Zamora Pérez, Ana Lourdes	es
dc.contributor.author	Lazalde Ramos, Blanca Patricia	es
dc.contributor.author	Martínez-Fierro, Margarita de la Luz	es
dc.contributor.author	González González, Rogelio	es
dc.contributor.author	Molina Frechero, Nelly	es
dc.contributor.author	Espinoza, Mario Alberto Isiordia	es
dc.contributor.author	Bologna Molina, Ronell	es
dc.date.accessioned	2018-05-02T12:04:11Z
dc.date.available	2018-05-02T12:04:11Z
dc.date.issued	2017	es
dc.identifier.citation	López-Verdín, Sandra ; Soto-Avila, Juan-José ; Zamora Pérez, Ana Lourdes ; Lazalde Ramos, Blanca Patricia ; Martínez-Fierro, Margarita de la Luz ; González González, Rogelio ; Molina Frechero, Nelly ; Espinoza, Mario Alberto Isiordia ; Bologna Molina, Ronell. Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 6 2017: 5-	es
dc.identifier.uri	http://hdl.handle.net/10550/65937
dc.description.abstract	The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the presence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immunohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method. Patients without cancer were included in the study as a control group for comparisons of the sE-cadherin levels. sE-cadherin levels in the saliva of patients without cancer were lower than those in patients with cancer, and the difference was statistically significant (p=0.031). Low mE-cadherin expression was statistically significantly associated with lymph node positivity (p=0.015) and advanced clinical stage (p=0.001). The inverse relationship between mE-cadherin and sE-cadherin was significant in terms of lymph node positivity (p=0.014) and advanced clinical stage (p=0.037). The results suggest that sE-cadherin levels are significantly increased in patients with oral cancer and that its low expression within the membrane as well as the progression of the disease appear to be inversely associated with levels of sE-cadherin in the saliva.	es
dc.title	Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.21907	es
dc.type.hasVersion	VoR	es_ES