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Lower lip squamous cell carcinoma in patients with photosensitive disorders : analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012

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Lower lip squamous cell carcinoma in patients with photosensitive disorders : analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012

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dc.contributor.author Borges, Jorena-Fraga-Pimenta es
dc.contributor.author Lanaro, Nattália-Di es
dc.contributor.author Bernardo, Vagner-Gonçalves es
dc.contributor.author Albano, Rodolpho M. es
dc.contributor.author Dias, Fernando es
dc.contributor.author Faria, Paulo Antonio Silvestre de es
dc.contributor.author Pinto, Luis-Felipe-Ribeiro es
dc.contributor.author Lourenço, Simone de Queiroz Chaves es
dc.date.accessioned 2018-05-02T12:37:42Z
dc.date.available 2018-05-02T12:37:42Z
dc.date.issued 2018 es
dc.identifier.citation Borges, Jorena-Fraga-Pimenta ; Lanaro, Nattália-Di ; Bernardo, Vagner-Gonçalves ; Albano, Rodolpho M. ; Dias, Fernando ; Faria, Paulo Antonio Silvestre de ; Pinto, Luis-Felipe-Ribeiro ; Lourenço, Simone de Queiroz Chaves. Lower lip squamous cell carcinoma in patients with photosensitive disorders : analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 1 2018: 2- es
dc.identifier.uri http://hdl.handle.net/10550/65963
dc.description.abstract Lower lip squamous cell carcinoma (LLSCC) is a common malignancy of the head and neck, being mainly a consequence of a chronic exposure to ultraviolet (UV) light solar radiation. Here, we evaluated the clinicopathological profile of patients with photosensitive disorders (xeroderma pigmentosum, lupus erythematosus and albinism) that developed LLSCC. Data from patients who had a diagnosed LLSCC with a prior xeroderma pigmentosum, lupus erythematosus or albinism diagnosis that were treated at INCA from 1999 to 2012 were collected from patients? medical records (n=16). The control group was composed of 68 patients with LLSCC without a medical history of photosensitivity. The clinicopathological data of this study population were collected and the association between these variables was analyzed by Fisher?s exact test. Survival curves were constructed using the Kaplan?Meier method and compared by log-rank test. All statistical analyses were performed using SPSS statistics package. The mean age of patients in the photosensitive and non-photosensitive groups was 42 years and 67 years, respectively (p<0.0001). A previous history of malignant diseases was more common in the photosensitive group (p=0.001). In both groups, most tumors showed a pathological stage I/II disease. Overall and cancer-specific survival were not statistically different. However, disease-free interval showed a significant difference (p=0.01) between the photosensitive and non-photosensitive patients. Photosensitive patients presented LLSCC at earlier age but it usually was not the primary tumor in these patients. Furthermore, a more aggressive pathological behavior was not seen when compared with tumors from non-photosensitive patients. The disease-free interval was lower in photosensitive patients, as expected. es
dc.title Lower lip squamous cell carcinoma in patients with photosensitive disorders : analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21960 es
dc.type.hasVersion VoR es_ES

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