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The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters

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The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters

dc.contributor.author	Patiño-Galindo, Juan Ángel
dc.contributor.author	Torres Puente, Manoli
dc.contributor.author	Bracho Lapiedra, Maria Alma
dc.contributor.author	Alastrué, Ignacio
dc.contributor.author	Juan, Amparo
dc.contributor.author	Navarro Ortega, David
dc.contributor.author	Galindo, María José
dc.contributor.author	Ocete Mochón, Dolores
dc.contributor.author	Ortega González, Enrique
dc.contributor.author	Gimeno Cardona, Concepción
dc.contributor.author	Belda, Josefina
dc.contributor.author	Domínguez, Victoria
dc.contributor.author	Moreno Muñoz, Rosario
dc.contributor.author	González Candelas, Fernando
dc.date.accessioned	2018-05-16T13:43:52Z
dc.date.available	2018-05-16T13:43:52Z
dc.date.issued	2017
dc.identifier.citation	Patiño-Galindo, Juan Ángel Torres Puente, Manoli Bracho Lapiedra, Maria Alma Alastrué, Ignacio Juan, Amparo Navarro Ortega, David Galindo, María José Ocete Mochón, Dolores Ortega González, Enrique Gimeno Cardona, Concepción Belda, Josefina Domínguez, Victoria Moreno Muñoz, Rosario González Candelas, Fernando 2017 The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters Scientific Reports 7 11584 1 10
dc.identifier.uri	http://hdl.handle.net/10550/66202
dc.description.abstract	HIV infections are still a very serious concern for public heath worldwide. We have applied molecular evolution methods to study the HIV-1 epidemics in the Comunidad Valenciana (CV, Spain) from a public health surveillance perspective. For this, we analysed 1804 HIV-1 sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2004 and 2014. These sequences were subtyped and subjected to phylogenetic analyses in order to detect transmission clusters. In addition, univariate and multinomial comparisons were performed to detect epidemiological differences between HIV-1 subtypes, and risk groups. The HIV epidemic in the CV is dominated by subtype B infections among local men who have sex with men (MSM). 270 transmission clusters were identified (>57% of the dataset), 12 of which included ≥10 patients; 11 of subtype B (9 affecting MSMs) and one (n = 21) of CRF14, affecting predominately intravenous drug users (IDUs). Dated phylogenies revealed these large clusters to have originated from the mid-80s to the early 00 s. Subtype B is more likely to form transmission clusters than non-B variants and MSMs to cluster than other risk groups. Multinomial analyses revealed an association between non-B variants, which are not established in the local population yet, and different foreign groups.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2017, vol. 7, num. 11584, p. 1-10
dc.subject	Epidemiologia
dc.subject	Malalties de transmissió sexual
dc.title	The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters
dc.type	journal article	es_ES
dc.date.updated	2018-05-16T13:43:52Z
dc.identifier.doi	10.1038/s41598-017-10286-1
dc.identifier.idgrec	121300
dc.rights.accessRights	open access	es_ES