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Oral health and systemic inflammatory, cardiac and nitroxid biomarkers in hemodialysis patients

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Oral health and systemic inflammatory, cardiac and nitroxid biomarkers in hemodialysis patients

dc.contributor.author	Cotic, Jasna	es
dc.contributor.author	Ferran, Monika	es
dc.contributor.author	Karisik, Jasmina	es
dc.contributor.author	Jerin, Ales	es
dc.contributor.author	Pussinen, Pirkko J.	es
dc.contributor.author	Nemec, Ana	es
dc.contributor.author	Pavlica, Zlatko	es
dc.contributor.author	Buturovic Ponikvar, Jadranka	es
dc.contributor.author	Petelin, Milan	es
dc.date.accessioned	2018-05-22T10:22:58Z
dc.date.available	2018-05-22T10:22:58Z
dc.date.issued	2017	es
dc.identifier.citation	Coti?, Jasna ; Ferran, Monika ; Kari?ik, Jasmina ; Jerin, Ales ; Pussinen, Pirkko J. ; Nemec, Ana ; Pavlica, Zlatko ; Buturovi? Ponikvar, Jadranka ; Petelin, Milan. Oral health and systemic inflammatory, cardiac and nitroxid biomarkers in hemodialysis patients. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 4 2017: 2-	es
dc.identifier.uri	http://hdl.handle.net/10550/66242
dc.description.abstract	Periodontal diseases have systemic inflammatory effects and have been adversely associated with cardiovascular diseases, which are also the most frequent cause of death in the end-stage renal disease. The aim of this cross-sectional study was to investigate the oral health and serum biomarkers among the hemodialysis (HD) patients in Slovenia. 111 HD patients were periodontally examined and their sera were assayed for C reactive protein (CRP), cardiac troponin T (TnT), nitrite/nitrate (NOx) and antibody levels to A. actinomycetemcomitans and P. gingivalis. The association of oral health with systemic response was analyzed with Kruskal-Wallis test, Fisher?s exact test and multivariate linear regression. Bleeding on probing without periodontal pockets was present in 5.2%, calculus without periodontal pockets in 42.1%, shallow periodontal pockets in 39.5% and deep periodontal pockets in 13.2% of dentate patients. There were 28.8% edentulous participants. 63.1% of the patients had CRP levels higher than 3 mg/L and 34.2% higher than 10 mg/L. TnT was detectable in all participants, with 25.2% exhibiting levels higher than 100 ng/L. The median level of NOx was 43.1 µmol/L. Participants with higher CRP were more likely to be edentulous and have higher TnT levels. A direct association of oral health with TnT or NOx was not detected. HD patients in Slovenia have compromised oral health and increased serum inflammatory and cardiac biomarkers. Edentulousness was an independent predictor for the increased CRP, indicating a need for improved dental care to retain the teeth as long as possible.	es
dc.title	Oral health and systemic inflammatory, cardiac and nitroxid biomarkers in hemodialysis patients	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.21629	es
dc.type.hasVersion	VoR	es_ES