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Clinical response to non-surgical periodontal treatment in patients with interleukin-6 and interleukin-10 polymorphisms

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Clinical response to non-surgical periodontal treatment in patients with interleukin-6 and interleukin-10 polymorphisms

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dc.contributor.author Chatzopoulos, Georgios S. es
dc.contributor.author Doufexi, Aikaterini es
dc.contributor.author Kouvatsi, A. es
dc.date.accessioned 2018-05-22T10:22:58Z
dc.date.available 2018-05-22T10:22:58Z
dc.date.issued 2017 es
dc.identifier.citation Chatzopoulos, Georgios S. ; Doufexi, Aikaterini ; Kouvatsi, A.. Clinical response to non-surgical periodontal treatment in patients with interleukin-6 and interleukin-10 polymorphisms. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 4 2017: 4- es
dc.identifier.uri http://hdl.handle.net/10550/66244
dc.description.abstract Genetic polymorphisms are commonly associated with altered transcriptional activity and possibly make individuals more susceptible to periodontal disease development, increased disease severity and poor treatment outcome. The study aimed to determine the effect of Interleukin-6 (IL-6) -572 G/C (rs1800796) and IL-10 -592 C/A (rs1800872) polymorphisms on the outcomes of non-surgical periodontal therapy in a Caucasian population. Sixty-eight patients with chronic periodontal disease were grouped according to their genotype: IL-6, IL-10, IL-6 and IL-10 susceptible (SCP) and non-susceptible (NSCP). All individuals were clinically evaluated at the first visit, and blood sample were collected from patients after checking the inclusion and exclusion criteria of the study. All patients received non-surgical periodontal therapy from a single-blinded periodontist. Clinical periodontal measurements were repeated 45 days after therapy. This population mean aged 47.63 years included 52.2% females and 58.2% non-smokers. Following DNA separation and genotyping, 65.7% of patients were homozygous carriers of the IL-6 - 572G; 49.3% were carriers of the IL-10 -592A- allele (AA and CA genotypes); and 35.8% carried SCP genotypes for both polymorphisms. The clinical parameters after therapy were not associated with the genotype status. The multiple logistic regression analysis did not show any statistically significant association between the genotypes and the variables tested. Within the limitations of this longitudinal study, it can be suggested that IL-6 -572 G/C and IL-10 -592 C/A polymorphisms as well as their combination do not influence the outcome of nonsurgical periodontal therapy in Caucasian patients diagnosed with chronic periodontal disease. es
dc.title Clinical response to non-surgical periodontal treatment in patients with interleukin-6 and interleukin-10 polymorphisms es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21795 es
dc.type.hasVersion VoR es_ES

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