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Clinicopathological analysis of head and neck rhabdomyosarcoma : a series of 10 cases and literature review

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Clinicopathological analysis of head and neck rhabdomyosarcoma : a series of 10 cases and literature review

dc.contributor.author	Corrêa Pontes, Flávia Sirotheau	es
dc.contributor.author	de Oliveira, Jonas-Ikikame	es
dc.contributor.author	de Souza, Lucas-Lacerda	es
dc.contributor.author	Almeida, Oslei Paes de	es
dc.contributor.author	Fregnani, Eduardo Rodrigues	es
dc.contributor.author	Vilela, Rafael-Sarlo	es
dc.contributor.author	Silva, Wanessa-Miranda	es
dc.contributor.author	Fonseca, Felipe Paiva	es
dc.contributor.author	Rebelo-Pontes, Hélder-Antônio	es
dc.date.accessioned	2018-05-23T08:27:54Z
dc.date.available	2018-05-23T08:27:54Z
dc.date.issued	2018	es
dc.identifier.citation	Corrêa Pontes, Flávia Sirotheau ; de Oliveira, Jonas-Ikikame ; de Souza, Lucas-Lacerda ; Almeida, Oslei Paes de ; Fregnani, Eduardo Rodrigues ; Vilela, Rafael-Sarlo ; Silva, Wanessa-Miranda ; Fonseca, Felipe Paiva ; Rebelo-Pontes, Hélder-Antônio. Clinicopathological analysis of head and neck rhabdomyosarcoma : a series of 10 cases and literature review. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 2 2018: 10-	es
dc.identifier.uri	http://hdl.handle.net/10550/66305
dc.description.abstract	To describe the clinicopathological characteristics of a series of head and neck rhabdomyosarcoma (RMS) and to review the literature. Cases diagnosed as RMS affecting the head and neck region were retrospectively retrieved from the files of two Brazilian institutions from January 2006 to January 2017. Data on clinical features (sex, age and affected site), microscopic subtype, immunohistochemical results, treatment employed and follow-up status were obtained from the patient?s medical charts. During the period considered, 10 cases of RMS were identified. Females predominated (4M:6F), the mean age at diagnosis was 16.5 years-old and the orbit was the most affected site (4 cases). Microscopically, most cases were classified as embryonal RMS (6 cases) and the Desmin/Myogenin/Myo-D1 immunohistochemical positivity was useful to confirm the diagnosis. Chemotherapy and radiotherapy were applied to 9 and 8 patients respectively, whereas 2 patients were treated by surgery. Recurrences occurred in 3 patients and distant metastasis in 2 cases. Nine patients were alive in their last follow-up, 3 of them with disease, whereas 1 patient died due to the disease. Head and neck RMS is an aggressive malignant neoplasm which demands especial concern to achieve early diagnosis and successful treatment.	es
dc.title	Clinicopathological analysis of head and neck rhabdomyosarcoma : a series of 10 cases and literature review	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.22106	es
dc.type.hasVersion	VoR	es_ES