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Outcome of CO2 laser vaporization for oral potentially malignant disorders treatment

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Outcome of CO2 laser vaporization for oral potentially malignant disorders treatment

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dc.contributor.author Cloitre, Alexandra es
dc.contributor.author Rosa, Rafael W. es
dc.contributor.author Arrive, Elise es
dc.contributor.author Fricain, Jean-Christophe es
dc.date.accessioned 2018-05-23T08:27:55Z
dc.date.available 2018-05-23T08:27:55Z
dc.date.issued 2018 es
dc.identifier.citation Cloitre, Alexandra ; Rosa, Rafael W. ; Arrive, Elise ; Fricain, Jean-Christophe. Outcome of CO2 laser vaporization for oral potentially malignant disorders treatment. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 2 2018: 16- es
dc.identifier.uri http://hdl.handle.net/10550/66311
dc.description.abstract Oral cancer is a public health issue worldwide. Oral potentially malignant disorders (OMPDs) are lesions of the oral mucosa that are predisposed to malignant transformation. The mainstay of OMPDs treatment around the world is now the carbon dioxide (CO2) laser but the reported recurrence and malignant transformation rates vary widely in the literature. We aimed to estimate the recurrence and the malignant transformation rates of OPMDs treated with CO2 laser at the University Hospital of Bordeaux, in France, from 2010 to 2014, and to identify associated factors with recurrence or malignant transformation. We conducted a retrospective study in patients with a minimum follow-up of 12 months. Collected variables included characteristics of the patients (gender, age, alcohol and tobacco consumption, previous diagnosis of graft-versus-host disease, previous treatments for OPMD or for upper aerodigestive tract cancers and human immunodeficiency virus infection), characteristics of the lesions (form, colour, size, location, degree of dysplasia), laser treatment outcome (complications, recurrence, malignant transformation). Twenty-five patients were included. Mean follow-up was 28.9 months. Recurrence was observed in 11 patients (44%). Annual recurrence rate was 18.3% and annual malignant transformation rate was 1.7%. Hyperplasia without dysplasia was the only factor found to be statistically associated with recurrence. Our results suggest that OMPDs treated by CO2 laser vaporization have high recurrence rates, particularly those presenting hyperplasia. A standardized definition of recurrence would be necessary for inter-study comparisons. Long-term follow-up is recommended in order to detect and treat squamous cell carcinoma in its early stages. es
dc.title Outcome of CO2 laser vaporization for oral potentially malignant disorders treatment es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21984 es
dc.type.hasVersion VoR es_ES

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