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One or two ligatures inducing periodontitis are sufficient to cause fatty liver

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One or two ligatures inducing periodontitis are sufficient to cause fatty liver

dc.contributor.author	Pessoa, Larissa-dos Santos	es
dc.contributor.author	da Silva, Felipe Rodolfo Pereira	es
dc.contributor.author	Alves, Even-Herlany-Pereira	es
dc.contributor.author	de Carvalho França, Luiz Felipe	es
dc.contributor.author	di Lenardo, David	es
dc.contributor.author	Carvalho, Joaquina-dos Santos	es
dc.contributor.author	Martins, Victor-Brito-Dantas	es
dc.contributor.author	Sousa, Francisca-Beatriz-de Melo	es
dc.contributor.author	Drumond, Karina-Oliveira	es
dc.contributor.author	Medeiros, Jand-Venes-Rolim	es
dc.contributor.author	de Oliveira, Jefferson-Soares	es
dc.contributor.author	Vasconcelos, Daniel Fernando Pereira	es
dc.date.accessioned	2018-05-28T10:45:23Z
dc.date.available	2018-05-28T10:45:23Z
dc.date.issued	2018	es
dc.identifier.citation	Pessoa, Larissa-dos Santos ; da Silva, Felipe Rodolfo Pereira ; Alves, Even-Herlany-Pereira ; de Carvalho França, Luiz Felipe ; di Lenardo, David ; Carvalho, Joaquina-dos Santos ; Martins, Victor-Brito-Dantas ; Sousa, Francisca-Beatriz-de Melo ; Drumond, Karina-Oliveira ; Medeiros, Jand-Venes-Rolim ; de Oliveira, Jefferson-Soares ; Vasconcelos, Daniel Fernando Pereira . One or two ligatures inducing periodontitis are sufficient to cause fatty liver. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 3 2018: 4-	es
dc.identifier.uri	http://hdl.handle.net/10550/66439
dc.description.abstract	Periodontitis is a chronic disease that due to an intense inflammatory response triggers systemic changes such as hepatic alterations. This study aimed to compare hepatic damage in rats that received experimental periodontitis at one or two periodontal sites with ligatures. Eighteen rats were separated into three groups: control, without ligature; periodontitis 1, with one ligature; and periodontitis 2, with two ligatures. The following parameters were assessed: gingival bleeding index, probing pocket depth, tooth mobility, alveolar bone loss, malondialdehyde (MDA) and myeloperoxidase (MPO) activity in periodontal tissue; histopathological evaluation of hepatic tissue (steatosis score); glutathione levels (GSH), MDA, MPO, cholesterol and triglycerides in the liver; and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Periodontal evaluation data showed that the periodontitis model worked well. The groups with periodontitis did not differ significantly in relation to MPO activity and MDA levels in the gingival samples, but they were significantly different when compared with the control group. Steatosis was observed in the histological analysis of the groups with periodontitis, but between the periodontitis groups, two ligatures did not cause increase in steatosis score. The levels of GSH, MDA, total cholesterol and triglycerides in the hepatic tissue were not altered between groups with periodontitis, but they showed significant differences in comparison with the control group. The activity of MPO in hepatic tissue and serum levels of AST and ALT did not present significant difference among the three groups. In conclusion, our results demonstrated that one or two ligatures inducing periodontitis were both sufficient to cause fatty liver. Steatosis caused by two ligatures did not present larger extension and severity than steatosis caused by one ligature.	es
dc.title	One or two ligatures inducing periodontitis are sufficient to cause fatty liver	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.22204	es
dc.type.hasVersion	VoR	es_ES