NAGIOS: RODERIC FUNCIONANDO

Association of time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Association of time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation

dc.contributor.author	Schmalz, Gerhard	es
dc.contributor.author	Berisha, Lisa	es
dc.contributor.author	Wendorff, Horst	es
dc.contributor.author	Widmer, Florian	es
dc.contributor.author	Marcinkowski, Anna	es
dc.contributor.author	Teschler, Helmut	es
dc.contributor.author	Sommerwerck, Urte	es
dc.contributor.author	Haak, Rainer	es
dc.contributor.author	Kollmar, Otto	es
dc.contributor.author	Ziebold, Dirk	es
dc.date.accessioned	2018-05-28T10:45:23Z
dc.date.available	2018-05-28T10:45:23Z
dc.date.issued	2018	es
dc.identifier.citation	Schmalz, Gerhard ; Berisha, Lisa ; Wendorff, Horst ; Widmer, Florian ; Marcinkowski, Anna ; Teschler, Helmut ; Sommerwerck, Urte ; Haak, Rainer ; Kollmar, Otto ; Ziebold, Dirk. Association of time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 3 2018: 12-	es
dc.identifier.uri	http://hdl.handle.net/10550/66442
dc.description.abstract	Aim of this study was to investigate the association of the time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected periodontal pathogenic bacteria of immunosuppressed patients after solid organ transplantation (SOT). 169 Patients after SOT (lung, liver or kidney) were included and divided into subgroups according their time under (0-1, 1-3, 3-6, 6-10 and >10 years) and form of immunosuppression (Tacrolimus, Cyclosporine, Mycophenolate, Glucocorticoids, Sirolimus and monotherapy vs. combination). Periodontal probing depth (PPD) and clinical attachment loss (CAL) were assessed. Periodontal disease severity was classified as healthy/mild, moderate or severe periodontitis. Subgingival biofilm samples were investigated for eleven selected potentially periodontal pathogenic bacteria using polymerasechainreaction. The mean PPD and CAL as well as prevalence of Treponema denticola and Capnocytophaga species was shown to be different but heterogeneous depending on time under immunosuppression (p<0.05). Furthermore, only the medication with Cyclosporine was found to show worse periodontal condition compared to patients without Cyclosporine (p<0.05). Prevalence of Porphyromonas gingivalis, Tannerella forsythia and Fusobacterium nucleatum was reduced and prevalence of Parvimonas micra and Capnocytophaga species was increased in patients under immunosuppression with Glucocorticoids, Mycophenolate as well as combination therapy. Time under and form of immunosuppression might have an impact on the clinical periodontal and microbiological parameters of patients after SOT. Patients under Cyclosporine medication should receive increased attention. Differences in subgingival biofilm, but not in clinical parameters were found for Glucocorticoids, Mycophenolate and combination therapy, making the clinical relevance of this finding unclear.	es
dc.title	Association of time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected bacteria of patients after solid organ transplantation	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.22238	es
dc.type.hasVersion	VoR	es_ES