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Reactivity of lithium β‑ketocarboxylates: the role of lithium salts
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Reactivity of lithium β‑ketocarboxylates: the role of lithium salts
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| Berton, Mateo Otao; Mello, Rossella C. C.; Williard, Paul G.; González Núñez, María Elena | |||
| Aquest document és un/a article, creat/da en: 2017 | |||
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| Lithium beta-ketocarboxylates 1(COOLi), prepared by the reaction of lithium enolates 2(Li+) with carbon dioxide, readily decarboxylate in THF solution unless in the presence of lithium salts, in which case they are indefinitely stable at room temperature in inert atmosphere. The availability of stable THF solutions of lithium beta-ketocarboxylates 1(COOLi) in the absence of carbon dioxide allowed reactions to take place with nitrogen bases and alkyl halides 3 to give alpha-alkyl ketones 1(R) after acidic hydrolysis. The sequence thus represents the use of carbon dioxide as a removable directing group for the selective monoalkylation of lithium enolates 2(Li+). The roles of lithium salts in preventing the decarboxylation and disproportionation reactions of lithium beta-ketocarboxylates 1(COOLi), and in determining the course of the reaction with bases and alkyl halides 3, are discussed. | |||
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